Mechanisms of retinal ganglion cell death in glaucoma » książka
Mechanisms of retinal ganglion cell death in glaucoma
ISBN-13: 9783639161656 / Angielski / Miękka / 2009 / 104 str.
Elevated intraocular pressure is the most significant risk factor in glaucoma but the mechanisms of retinal ganglion cell death in remain incompletely understood. Animal models of glaucoma provide a way to study the possible pathogenesis of glaucomatous retinal ganglion cell death and to assess potential neuroprotective strategies. In this volume, Dr Keith Martin describes in detail how a trabecular laser glaucoma model can be used to study changes occuring in the retina and optic nerve of eyes with elevated intraocular pressure. The possible involvement of retinal glutamate transporters in glaucoma is explored, hinting at possible new treatment approaches. Dr Martin goes on to describe in detail the techniques that led to the first successful use of neurotrophic factor gene therapy to reduce retinal ganglion cell death in experimental glaucoma.
Elevated intraocular pressure is the most significantrisk factor in glaucoma but the mechanisms of retinalganglion cell death in remain incompletelyunderstood. Animal models of glaucoma provide a wayto study the possible pathogenesis of glaucomatousretinal ganglion cell death and to assess potentialneuroprotective strategies. In this volume, Dr Keith Martin describes in detailhow a trabecular laser glaucoma model can be used tostudy changes occuring in the retina and optic nerveof eyes with elevated intraocular pressure. The possible involvement of retinal glutamatetransporters in glaucoma is explored, hinting atpossible new treatment approaches. Dr Martin goes onto describe in detail the techniques that led to thefirst successful use of neurotrophic factor genetherapy to reduce retinal ganglion cell death inexperimental glaucoma.
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