Mechanisms of Carcinogenesis

ISBN-13: 9780898389913 / Angielski / Twarda / 1988 / 200 str.

Elizabeth K. Weisburger

Opis

but also the possibility of intervention in specific stages. In Human behavior, including stress and other factors, plays an important role in neoplasia, although too little is known addition, variables which affect cancer development as well on the reasons for such development. Carcinogens, which as some endogenous factors can be better delineated help initiate the neoplastic process, may be either synthetic through such investigations. The topics of this volume encompass premalignant non or naturally-occurring. Cancer causation may be ascribed to invasive lesions, species-specific aspects of carcinogenicity, certain chemicals, physical agents, radioactive materials, viruses, parasites, the genetic make-up of the organism, and radiation, viruses, a quantum theory of carinogenesis, onco bacteria. Humans, eumetazoan animals and vascular plants genes, and selected environmental carcinogens. are susceptible to the first six groups of cancer causes, whe reas the last group, bacteria, seems to affect only vascular plants. Neoplastic development may begin with impairment ofJmdy defenses by a toxic material (carcinogen) which acts as an initiator, followed by promotion and progression to an overt neoplastic state. Investigation of these processes Series Editor Volume Editor allows not only a better insight into the mechanism of action Hans E. Kaiser Elizabeth K. Weisburger vii ACKNOWLEDGEMENT Inspiration and encouragement for this wide ranging project on cancer distribution and dissemination from a comparative biological and clinical point of view, was given by my late friend E. H. Krokowski."

Spis treści

1. The influence of human behavior on neoplastic progression.- 2. The influence of stressors on the progression of neoplastic change.- 3. The seven types of causes of neoplastic growth — an organismic view.- 4. Chemoprevention research.- 5. Premalignant and non-invasive lesions of the urinary bladder.- 6. Species-specific aspects of the carcinogenicity of chloroform.- 7. Carcinogenic effects of ionizing radiation.- 8. Selected aspects of viral carcinogenesis.- 9. The quantum theory of carcinogenesis — a short review.- 10. Cellular oncogene activation by chromosomal translocation.- 11. Amplification of the oncogene N-Myc as a correlate to advanced stage in human neuroblastomas.- 12. Potential roles of activated proto-oncogenes in malignant progression.- 13. Oncogenes and their encoded products as targets for cancer therapy.- 14. Methods to study RAS oncogene-mediated induction of the metastatic phenotype.- 15. Oncogene products as potential therapeutic targets for control of established metastatic disease.- 16. Neoplastic cell stages and progression in experimental hepatocarcinogenesis.- 17. Characterization of eleven important transplantable murine tumors from the standpoint of morphology, pyrimidine biosynthesis and responsiveness to pyrimidine antimetabolites.- 18. Use of organ expiant and cell culture in cancer research.- 19. Season of operation and differential long-term progression: clinical, statistical, and psychological issues.- 20. Endogenous factors affecting the progression of carcinogen-induced rat mammary carcinomas.- 21. Age factors in the presence of selected neoplasms.- 22. Extremely low frequency electromagnetic fields as possible promotors of carcinogenesis.- 23. Medical geography and neoplasms.- Index of subjects.