Mechanisms in B-Cell Neoplasia 1992: Workshop at the National Cancer Institute, National Institutes of Health, Bethesda, MD, Usa, April 21-23, 1992

ISBN-13: 9783642776359 / Angielski / Miękka / 2011 / 499 str.

Michael Potter; Fritz Melchers

Opis

Main topics covered: B-Cell Development; Immunoglobulin Gene Rearrangement; Multiple Myeloma, Plasmactomas; Lymphomas: B-CLL, Folli- cular Lymphomas BCL-2, BCL-1; Lymphomas: EBV, AIDS Associa- ted Lymphomas; Oncogenes and Transcriptional Factors (text to follow)

Spis treści

B-Cell Development.- Progenitor and Precursor B Lymphocytes of Mice. Proliferation and Differentiation In Vitro and Population, Differentiation and Turnover in SCID Mice In Vivo of Normal and Abnormal Cells.- Isolation and Characterization of a Stromal Cell Line.- Growth and Differentiation of a Bipotent Precursor of B Cells and Macrophages.- Control of Intramarrow B-Cell Genesis by Stromal Cell-Derived Molecules.- Establishment of a Reproducible Culture Technique for the Selective Growth of B-Cell Progenitors.- Multiple Steps in the Regulation and Dysregulation of B-Cell Precursors in the Bone Marrow: c-myc Expression, In Vivo Effects of Interleukins 1 and 7, and Stromal Cell Interactions.- The Purification of B-Cell Precursors From Mouse Fetal Liver.- BCR/ABL Enhances Growth of Multipotent Progenitor Cells But Does Not Block Their Differentiation Potential In Vitro.- Repopulation of SCID Mice with Fetal-Derived B-Lineage Cells.- Early B-Cell Repertoires.- In Vitro Growth and Maturation of Human B-Cell Precursors.- Modulation of Signal Transduction in Phosphocholine-Specific B cells from ?? Transgenic Mice.- Immunoglobulin Gene Rearrangement.- Activities Involved in V(D)J Recombination.- Double-Strand Breaks Associated with V(D)J Recombination at the TCR? Locus in Murine Thymocytes.- Replication, Transcription, CpG Methylation and DNA Topology in V(D)J Recombination.- Rearrangement and Expression of Immunoglobulin Genes in Transgenic Mice.- Regulation of Switch Recombination to the Murine ? 1 Gene.- Protein Recognition Motifs of S? 3 DNA Are Statistically Correlated with Switch Recombination Breakpoints.- Regulation of Transcription of the Germline Immunoglobulin ? Constant Region Gene.- S?BP/BSAP/NF-S? B1, a Murine and Human B-Cell Stage Specific Nuclear Factor with DNA Binding Specificity Implying Roles in Switch-Recombination and Transcription.- Multiple Myeloma, Plasmacytomas.- Multidrug Resistance of a Continuously Differentiating Monoclonal B Lineage in the Blood and Bone Marrow of Patients with Multiple Myeloma.- Expression of Multiple Adhesion Molecules on Circulating Monoclonal B Cells in Myeloma.- Circulating Peripheral Blood Plasma Cells in Multiple Myeloma.- Circulating B Lymphocytes in Multiple Myeloma Patients Contain an Autocrine IL-6 Driven Pre-Myeloma Cell Population.- In Which Cells Does Neoplastic Transformation Occur in Myelomatosis?.- Differential Expression of c-myc-mRNA and c-MYC-Protein During Terminal Neoplastic B-Cell Differentiation.- Genes Expressed Selectively in Plasmacytomas: Markers of Differentiation and Transformation.- PCS, a Gene Related to the Immunoglobulin Super Family of Axonal Glycoproteins is Expressed in Murine Plasma Cell Tumors.- Inhibiting IL-6 in Human Multiple Myeloma.- Pathophysiology of Human Multiple Myeloma- Recent Advances and Future Directions.- An Exceptional Mouse Plasmacytoma with a New Kappa/N-myc [T(6; 12) (C1 ; B)] Translocation Expresses N-myc But Not c-myc.- Experimental Model of Human Light-Chain-Associated Disease.- Lymphomas: B-CLL, Follicular Lymphomas BCL-2, BCL-1.- On the Role of Endogenously Produced TNF-? and IL-6 as Regulators of Growth and Differentiation of B-Type Chronic Lymphocytic Leukemia Cells in Vitro.- BCL-2 in B-Chronic Lymphocytic Leukemia.- Subcellular Localization of BCL-2 Protein.- Collaboration of PIM-1 and BCL-2 in Lymphomagenesis.- The Role of bcl-2 in Lymphoid Differentiation and Neoplastic Transformation.- Evolution of Leukemic Heterogeneity of Human B-CLL Lymphocytes Between and Within Patients.- p53 Mutations in B-Cell Chronic Lymphocytic Leukemia.- Burkitts Lymphoma Cells Frequently Carry Monoallelic DJ Rearrangements.- Centrocytic Lymphoma: a B-Cell Non-Hodgkin’s Lymphoma Characterized by Chromosome 11 BCL-1 and PRAD 1 Rearrangements.- Two Surface Antigen Targets for Immunotoxin-Mediated Elimination of Normal and Neoplastic Murine B Cells.- Generation and Differentiation Potential of Retrovirus-lmmortalized Mature Murine B Cells.- The Role of Growth Factors in Human Lymphomas.- Production of Interleukin-6 in High Grade B Lymphomas.- Lymphomas: EBV, AIDS Associated Lymphomas.- Mutational Analysis of the Transforming Function of the EBV Encoded LMP-1.- Integration of EBV in Burkitt’s Lymphoma Cells.- The Oncogenic Potential of Epstein-Barr Virus Nuclear Antigen 1 in Transgenic Mice.- AIDS Associated Non-Hodgkin’s Lymphomas Represent a Broad Spectrum of Monoclonal and Polyclonal Lymphoproliferative Processes.- Lymphomas in Mice with Retrovirus-lnduced Immunodeficiency.- Does HIV Infection of B Lymphocytes Initiate AIDS Lymphoma? Detection by PCR of Viral Sequences in Lymphoma Tissue.- Oncogenes and Transcriptional Factors.- Lymphocyte Activation and the Family of NF-?B Transcription Factor Complexes.- Transactivation of the c-myc Gene by HTLV-1 tax is Mediated by NF-?B.- Cloning and Characterization of DNA Binding Factors Which Bind Sequences Required for Proper c-myc Initiation.- Transcriptional Activities of the Myc and Max Proteins in Mammalian Cells.- c-myc Transactivates the Ornithine Decarboxylase Gene.- v-Raf/v-Myc Synergism in Abrogation of IL-3 Dependence: v-Raf Suppresses Apoptosis.- Cyclins in the Cell Cycle: An Overview.- The Localization of the Products of the c-cbl and v-cbl Oncogenes During Mitosis and Transformation.- V-rel and C-rel Modulate the Expression of Both Bursal and Non-Bursal Antigens on Avian B-Cell Lymphomas.- Why Don’t Germline Mutations in RB1 Predispose to Leukemia?.- Loss of p53 Expression in Myc-induced B Lineage Tumors.

O autorze

Michael Potter is Reader in the Philosophy of Mathematics at Cambridge University. He is the author of Sets (OUP, 1990), Reason's Nearest Kin (OUP, 2000), Set Theory and its Philosophy (OUP, 2004), and Mathematical Knowledge (edited with Mary Leng and Alexander Paseau, OUP, 2007).