Mechanisms and Emerging Therapies in Tremor Disorders

ISBN-13: 9783031261275 / Angielski

Giuliana Grimaldi; Mario Manto

Opis

Tremor is intimately linked to the numerous interactions of the central and peripheral nervous system components tuning motor control, from the cerebral cortex to the peripheral effectors. Activities of central generators, reflex loop delays, inertia, stiffness, and damping are all factors that influence the features of tremor. This completely updated new edition discusses the pathophysiology of tremor, including membrane mechanisms and rodent models, the advances in genetics, and the musculoskeletal models pertinent to body oscillations. The main forms of tremor encountered during clinical practice are considered, taking into account neuroimaging aspects. The book covers recent advances in methodologies and techniques of assessment and provides practical information for daily management. This new edition is informed by the guidelines of the Tremor Task Force of the International Parkinson and Movement Disorders Society.  New chapters include Classification of Tremors, Medically Induced Tremors, Resting State fMRI, and Gabaergic Pathways. In addition to pharmacological treatments, neurosurgical approaches such as deep brain stimulation (DBS) and thalamotomy are discussed. Emerging techniques under development are also introduced.

Spis treści

PART I. Fundamental Aspects

Chapter 1. Definition of Tremor

Chapter 2. Membrane Mechanisms of Tremor

Chapter 3 Advances in the Genetics of Human Tremor

Chapter 4. Two origins of tremors related to the Guillain-Mollaret triangle: the forward model-related tremor and the inferior olive oscillation-related tremor

PART II.Tremor in Clinical Practice

Chapter 5. Physiologic Tremor

Chapter 6. Rest Tremor

Chapter 7. Postural Tremors

Chapter 8. Isometric Tremor

Chapter 9. Essential Tremor and Other Forms of Kinetic Tremor

Chapter 10. Cerebellar lesions and tremor

Chapter 11. Orthostatic Tremor

Chapter 12. Posttraumatic Tremor and Other Posttraumatic Movement Disorders

Chapter 13 Tremor in Childhood

Chapter 14. Metabolic Causes of Tremor

Chapter 15. Drug-Induced Tremor

Chapter 16. Tremor: The Clinical Approach to Reach the Diagnosis

PART III. Assessment of tremor

Chapter 17. Signal Processing

Chapter 18. Diffusion imaging in Tremor

Chapter 19. The role of the noradrenergic system in tremor pathogenesis

Chapter 20. Metabolic Networks in Parkinson’s Disease

PART IV. Therapies

Chapter 21. Deep brain stimulation for tremor

Chapter 22 Mechatronic Devices for Upper Limb Tremor

O autorze

Giuliana Grimaldi, MD, PhD, is a neurologist.  She is affiliated with Unità Spinale, ASP Palermo, Italy. She is a member of the Society for Cerebellar Research (SRC).

Mario Manto, MD, PhD is a neurologist. He is researcher at the FNRS-Belgium, Head of the Department of Neurology, CHU-Charleroi, and Professor of Neuroanatomy at U Mons.  He is the founding and current editor of the international journal The Cerebellum (Springer). He is the President of the Medical Board of Euro-Ataxia. He has founded the Society for Research on the Cerebellum.  He is editor of the Contemporary Clinical Neuroscience series (Springer).