Mechanical and Chemical Signaling in Angiogenesis

ISBN-13: 9783642308550 / Angielski / Twarda / 2012 / 282 str.

Cynthia A Reinhart-King

Opis

This volume describes and discusses recent advances in angiogenesis research. The chapters are organized to address all biological length scales of angiogenesis: molecular, cellular and tissue in both in vivo and in vitro settings. Specific emphasis is given to novel methodologies and biomaterials that have been developed and applied to angiogenesis research. Angiogenesis experts from diverse fields including engineering, cell and developmental biology, chemistry and physics will be invited to contribute chapters which focus on the mechanical and chemical signals which affect and promote angiogenesis.

Spis treści

Mechanical and chemical regulation of arterial and venous specification.- Mechanosensory Pathways in Angiocrine Mediated Tissue Regeneration.- Microfluidic devices for quantifying the role of soluble gradients in early angiogenesis.- Reactive oxygen species in physiologic and pathologic angiogenesis.- Microfluidic Devices for Angiogenesis.- Vascular cell physiology under shear flow: role of cell mechanics and mechanotransduction.- Matrix Mechanics and Cell Contractility in Angiogenesis.- Computational modeling of angiogenesis: towards a multi-scale understanding of cell-cell and cell-matrix interactions.- ECM Remodeling in Angiogenesis.- Barrier maintenance in neovessels.- Computational Models of Vascularization and Therapy in Tumor Growth.- Biomaterials for Cell-Based Therapeutic Angiogenesis.- Translation of Pro-Angiogenic and Anti-Angiogenic Therapies into Clinical Use.

Blurb

This volume of Studies in Mechanobiology, Tissue Engineering and Biomaterials describes the most recent advances in angiogenesis research at all biological length scales: molecular, cellular and tissue, in both in vivo and in vitro settings.  Angiogenesis experts from diverse fields including engineering, cell and developmental biology, and chemistry have contributed chapters which focus on the mechanical and chemical signals which affect and promote blood vessel growth. Specific emphasis is given to novel methodologies and biomaterials that have been developed and applied to angiogenesis research.