Measurement of Risks

ISBN-13: 9781468440546 / Angielski / Miękka / 2012 / 550 str.

George G. Berg

Spis treści

The risks of measuring risk.- Session I: Statistical Inference of Risks.- The proper interpretation of significance tests in risk assessment.- Remarks on sequential designs in risk assessment.- Epidemiologic studies of toxic response — significance requirements.- Biological models in epidemiology: radiation carcinogenesis.- Session II: Risks of Prenatal Exposures.- Dose-response relationships for adult and prenatal exposures to methylmercury.- Risk factors for deficits in early cognitive development.- Utilization of critical periods during development to study the effects of low levels of environmental agents.- Epidemiologic studies of environmental exposures in human reproduction.- Session III: Risks of Contaminated Air and Drinking Water.- Health risks of lead as judged from autopsy material.- Use of tests of pulmonary function to measure effect of air pollutants.- Experimental evaluation of air pollutants in humans as a basis for estimating risk.- Problems and possibilities of determining the carcinogenic potency of inhalable fibrous dusts and polycyclic aromatic hydrocarbons.- Session IV: Comparative Risks of Energy Sources.- Some probabilistic aspects of safety assessment.- What is the total risk of energy systems?.- Have the nuclear power risk assessors failed?.- Session V: Genetic and Cancer Hazards.- Cytogenetic bases for risk inference.- Problems and solutions in the estimation of genetic risks from radiation and chemicals.- Evaluation of genetic risks.- Session VI: Extrapolation to Low Doses.- Extrapolation from long term low dose animal studies -I. Review.- Extrapolation from long term low dose animal studies -II. The ED01 study.- The shapes of the radiation dose — mutation response curves in Drosophila: mechanisms and implications.- The cancer risk from low level radiation.- A simple threshold model for the classical bioassay problem.- A biological basis for the linear non-threshold dose — response relationship for low-level carcinogen response.- Participants.