Maternal serum PlGF and PAPP-A : A prospective observational study

ISBN-13: 9783330075726 / Angielski / Miękka / 2017 / 52 str.

Eui Hyeok Kim

Opis

To examine the first-trimester maternal serum placental growth factor (PlGF) and pregnancy-associated plasma protein A (PAPP-A) levels in pregnancies associated with pre-eclampsia (PE) or small-for-gestational-age (SGA) infants, and determine the predictive accuracy of PlGF and of PAPP-A for either PE or SGA infants. This prospective, observational study included 175 pregnant women, and of these women, due to participant withdrawal or loss to follow-up, delivery data were collected from the medical records of 155 women, including 4 who had twin pregnancies. The women's maternal history was recorded, and the PlGF and PAPP-A levels at 11 to 13 gestational weeks were measured. During the second trimester, the maternal uterine artery's systolic/diastolic ratio was measured. Multiples of the median (MoM) of PlGF and PAPP-A were determined, and the associations of these values with the risk factors of SGA and PE were evaluated. Logistic regression analysis was used to determine whether PlGF and PAPP-A are useful markers for predicting SGA infants. PlGF and PAPP-A are potentially useful as first-trimester markers for SGA infants and some hypertensive disorders of pregnancy.

O autorze

Prof. Eui Hyeok Kim: March 2007 - present - Department of Obstetrics & Gynecology, Division of Maternal-Fetal, National Health Insurance Ilsan Hospital, Republic of Korea. March 2007 - present - Clinical Professor of Obstetrics & Gynecology, Yonsei University Medical Center, Republic of Korea.