Mass Spectrometry in Cancer Research

ISBN-13: 9780849301674 / Angielski / Twarda / 2002 / 576 str.

John Roboz

Opis

Cancer research is becoming multidisciplinary. The complex structural and therapeutic problems require synergistic approaches employing an assortment of biochemical manipulations, chromatographic or electrophoretic separations, sequencing strategies, and more and more mass spectrometry.
Mass Spectrometry in Cancer Research provides a broad examination of current strategies and techniques and their application to the study of:
(i) occupational and environmental carcinogens;
(ii) antineoplastic and chemopreventive agents;
(iii) pertinent proteins, lipids, nucleic acids and glycoconjugates. Also included are a chapter on instrumentation and methodologies for biologists and physicians and a brief review of the relevant concepts of cancer biology and medicine for mass spectrometrists.
This book is intended for: mass spectrometrists in research or those providing core services; researchers in biological, medical, pharmaceutical or environmental sciences; physicians in academic medicine; and academic/industrial research managers."

Recenzje

"This is a unique and very useful tool for biologists interested in mass spectrometry. Written with biologists in mind, it provides a good background for novices in the field and illustrates the potential of mass spectrometry in molecular biology and oncology. …it serves to connect these fields for a wide range of scientists. 4 stars!"
- Victor V. Levenson, MD, PhD, Northwestern University Medical School, Doody's Notes

"…an invaluable resource for mass spectrometrists. The text provides a myriad of experimental applications and strategies for the MS analyses of molecules that are central to the development and prevention of cancer. All mass spectrometrists who are interested in doing cancer research should procure a copy."
- M. Paul Chiarellia, Loyola University, in Journal of the American Society for Mass Spectrometry, Volume 14, Issue 1

Spis treści

OVERVIEW AND SCOPE OF APPLICATIONS The Essentials Functions and Types of Instrument Components Measures of Performance Information from Mass Spectra and Scope of ApplicationsINSTRUMENTATION AND TECHNIQUES OF MASS SPECTROMETRY Ion Sources Mass Analyzers Ion Current Detectors Mass Spectrometry-Mass Spectrometry (MS/MS) Identification and Quantification ResourcesRELEVANT CONCEPTS OF CANCER MEDICINE AND BIOLOGY Classification and Epidemiology Cellular Proliferation and Communication Genetic Abnormalities in Cancer Tumor Immunology Diagnosis and Treatment Some Pertinent Experimental MethodsMETABOLISM AND BIOMARKERS OF CARCINOGENS Classification, Mechanisms of Action and Biomarkers Occupational Carcinogens Environmental Carcinogens DNA Damage by Radiation and OxidationANTINEOPLASTIC AND CHEMOPREVENTIVE AGENTS Cytotoxic Therapy Endocrine Therapy Targeted Drug Delivery and Therapy Nutritional and Chemical Prevention STRATEGIES, TECHNIQUES AND APPLICATIONS IN CANCER BIOCHEMISTRY AND BIOLOGY Proteins and Peptides Lipids Oligonucleotides and Nucleic Acids Carbohydrates and GlycoconjugatesREFERENCESINDEX

O autorze

John Roboz