Marek's Disease: Scientific Basis and Methods of Control

ISBN-13: 9781461296355 / Angielski / Miękka / 2011 / 360 str.

L. N. Payne

Opis

Take a disease of complex pathology with inflammatory and neoplastic features, which affects lymphoid and neural tissues, belonging to a disease group which killed one chicken in five, and which defied efforts to understand and control it for lOre than 50 years, and one can begin to appreciate the interest Marek's disease has received. Canpound these characteristics with the finding of the causal herpesvirus, its recog nition as the neoplasm first discovered to be so caused, and its pre vention by vaccination, and the special place of Marek's disease in veterinary medicine and comparative oncology becomes clear. This book sets out to provide an authoritative and corrprehensive account of knowledge of Marek's disease and its control. I hope that it will be of value to veterinary research workers, teachers and students who need information about the disease, to veterinarians, poultrymen and vaccine manufacturers who have to diagnose and control it, and to oncologists in other fields interested in comparative aspects. other reviews of the disease exist, of course, but this is the first multi authored book devoted to the subject."

Spis treści

1. Historical review.- 1. Introduction.- 2. József Marek and the first description of Marek’s disease.- 3. Classical studies, 1920–1939.- 4. The middle period, 1940–1959.- 5. Events since 1960.- 2. Clinical disease and its economic impact.- 1. Introduction.- 2. Occurrence of infection and disease.- 3. The disease during production.- 4. The disease at slaughter.- 5. Economic loss from disease.- 6. Conclusions.- 3. Pathology.- 1. Introduction.- 2. Gross appearances.- 3. Histopathological and ultrastructural appearances.- 4. Lymphoma-derived cell lines.- 5. Transplantable lymphomas.- 6. Factors affecting pathogenesis.- 4. Characteristics of the virus.- 1. Introduction.- 2. Virus strains.- 3. Physical and chemical properties.- 4. Isolation and cultivation.- 5. Virus replication.- 6. Viral antigens.- 7. Concluding remarks.- 5. Molecular biology of the virus.- 1. Introduction.- 2. Viral deoxyribonucleic acid.- 3. Viral proteins.- 4. Replication.- 5. Oncogenesis.- 6. Concluding remarks.- 6. Laboratory diagnosis.- 1. Introduction.- 2. Diagnosis of a field outbreak.- 3. Diagnosis of infection.- 7. Immunity.- 1. Introduction.- 2. Expression of impunity.- 3. Immune responses to Marek’s disease-associated antigens.- 4. Contribution of immune responses to the expression of immunity.- 5. Immunosuppression.- 8. Principles of vaccination.- 1. Introduction.- 2. Types of vaccine.- 3. Responses to vaccination.- 4. Mechanisms of protection.- 5. Factors affecting vaccine efficacy.- 6. Investigation of vaccine failures.- 7. Comparative efficacy of vaccines.- 8. Strategies and perspectives.- 9. Production of vaccines.- 1. Introduction.- 2. Production methods.- 3. Conclusion.- 10. Quality control and standardization of vaccines.- 1. Introduction.- 2. Safety.- 3. Efficacy.- 4. Purity.- 5. Standard preparations.- 6. Recommended tests.- 11. Genetic resistance.- 1. Significance and historical aspects of genetic resistance.- 2. Expression of resistance.- 3. Mechanism of genetic resistance.- 12. Spread of Marek’s disease.- 1. Introduction.- 2. Spread of infection.- 3. Flock infection.- 4. Factors affecting the incidence of Marek’s disease.- 13. Control of Marek’s disease by the poultry industry: practical considerations.- 1. Introduction.- 2. Control by hygiene.- 3. Breeding for resistance.- 4. Control by vaccination.