Managing Discovery in the Life Sciences: Harnessing Creativity to Drive Biomedical Innovation

ISBN-13: 9781107130906 / Angielski / Twarda / 2018 / 554 str.

Philip A. Rea; Mark V. Pauly; Lawton R. Burns

Opis

This book addresses in roughly equal measure the science and management behind several recent marketable biomedical innovations.

Recenzje

'This new study by Philip A. Rea, Mark V. Pauly, and Lawton R. Burns provides useful information and insightful analyses of the biomedical innovation process.' Henry Grabowski, Professor Emeritus of Economics, Duke University, North Carolina

Spis treści

Preface; 1. Discoveries now and then: shifting incentives and expectations Mark V. Pauly, Philip A. Rea and Lawton R. Burns; 2. Pharma trends: not what they seem Kyle Myers and Mark V. Pauly; 3. Profit maximizing drug firms: models and myths Vicki Chen and Mark V. Pauly; Transitional note: introduction to the case studies; 4. The Statins: cholesterols 'penicillins' Philip A. Rea; 5. ACE inhibitors: kidney clamps, snake venoms and peptidomimetics Alec Ren and Philip A. Rea; 6. Angioplasty: catheters, guidewires and balloons Simon Basseyn, Sourav Bose, Lawton R. Burns and Chris Groskaufmanis; 7. Hepatitis C: when cures and prices go viral Stephen Goldstein, Peter M. Stokes, Connie Lu and Philip A. Rea; 8. Alzheimer's: America's new most feared disease Julian Pei, John Q. Trojanowski, Peter M. Stokes, Katherine Clark, Mark V. Pauly and Philip A. Rea; 9. Metformin: to the brink and back Anderson Y. Tien and Philip A Rea; 10. Medical genomics: personalized precision Marc S. Williams; 11. Gleevec: from broken chromosomes to precision cancer therapy Vivek Nimgaonkar and Philip A. Rea; 12. Regeneron: agility, resilience and balance Lawton R. Burns, Alex Rosen, Steven Nichtberger and Philip A. Rea; 13. Avastin and Lucentis: both for eyesight in hindsight Osama Ahmed, Mark V. Pauly, Peter M. Stokes and Philip A. Rea; 14. CAR T-cell therapy: cures for ALL and more? Stephen Goldstein, Amy Le and Philip A. Rea; 15. Organizing discovery: wild ducks nested in multilevel ecosystems Lawton R. Burns and Philip A. Rea; 16. Can government help with the creatively unexpected? Mark V. Pauly, Lawton R. Burns and Philip A. Rea; Appendix: three key elements in the discovery process: historical and philosophical antecedents Mark V. Pauly; Index.