Management of Hypertension: Current Practice and the Application of Landmark Trials

ISBN-13: 9783319929453 / Angielski / Twarda / 2018 / 302 str.

Vasilios Papademetriou; Emmanuel A. Andreadis; Charalampia Geladari

Recenzje

"The book is intended for medical scientists, researchers, and physicians who specialize in hypertension treatment. The book is outstanding in providing the landmark studies that have changed the practice of the management of hypertension. ... I would recommend this book to anyone interested in this exciting and important field." (Sanbir S Sidhu, Doody's Book Reviews, May 24, 2019)

Spis treści

 

SECTION ONE: INTRODUCTION TO MEDICAL RESEARCH

 

1. The importance of applying evidence-based medicine in clinical practice.

2. How to read and understand a scientific paper?

3. Medical Biostatistics; The basics

 

 

 

SECTION TWO: MAJOR TRIALS IN HYPERTENSION RESEARCH

 

4.       Is blood pressure related to increased cardiovascular risk?

 

5.       The VA Cooperative Studies – The First RCTs of Hypertension anywhere in the world.

6.        What is the role of dietary modifications in controlling blood pressure?

7.       Hypertension management in the elderly

 

8.       Hypertension management in African Americans

 

9.       Hypertension management in diabetics

 

10.   Outcomes of different antihypertensive regimens

11.   Comparison of combination therapies in the treatment of hypertension

12.   What is the goal of treatment?

13.   Can we prevent hypertension?

 

SECTION THREE: BLOOD PRESSURE ASSESSMENT METHODS USED IN LANDMARK TRIALS

14.   Methods of blood pressure assessment used in milestone hypertension trials

SECTION FOUR: PIONEERS IN HYPERTENSION RESEARCH

15.   Marvin Moser

16.   Irvine Page

17.   Edward Freis

18.   Stevo Julius

 

SECTION FIVE: CLOSING REMARKS

19.   The Future in Hypertension Research

 

 

 

O autorze

Dr Vasilios Papademetriou, MD, is a professor of medicine at Georgetown University School of Medicine, and staff cardiologist at Veterans Affairs Medical Centre in Washington, DC. He is the director of cardiovascular research, interventional hypertension and vascular medicine program, and co-director of the Cardiac Catheterization Laboratory at the Veterans Affairs Medical Centre. Dr Papademetriou's clinical interests include cardiac catheterization, PCI/STENTS, myocardial biopsies, pericardiocentesis, stress and transesophageal echocardiography, and revascularization of high risk patients. He runs a large clinic of patients with resistant hypertension and dyslipidemia, while his research is focused on hypertension and vascular biology, dyslipidemia, atherosclerosis, acute coronary syndromes/acute MI, and cardiovascular complications of diabetes. He has special interest in device-based treatment of patients with resistant hypertension and he is one of the principal investigators of the Renal Denervation projects. He has been a principal investigator for many “investigator initiated” and multicenter clinical trials and received numerous research grants from both public funding and industrial sponsors.

Dr Emmanuel A. Andreadis, MD, PhD is the director of the Fourth Department of Internal Medicine and the Head of the Hypertension and Cardiovascular Disease Prevention Center at Evangelismos General Hospital, in Athens, Greece, which has been recognized as an ESH Center of Excellence since 2012. Recently, Dr Andreadis and the Center became affiliated with the Hypertension and Vascular Medicine Clinic of the Veterans Affairs Medical Center, in Washington, DC, USA. He trained extensively in hypertension at the University Department of Medicine & Therapeutics and the Glasgow Blood Pressure Clinic, Western Infirmary, Glasgow, UK, and he is an ESH Clinical Hypertension Specialist. He is also a European Fellow on Medical Angiology having trained at the Saint Mary’s Hospital, in London, UK. Dr Andreadis is a member of the European Society of Hypertension and the Hellenic Society of Hypertension. His research focuses on hypertension and especially on blood pressure monitoring. He is a highly talented and experienced clinician, with over 35 years of experience in hospital and clinic settings in both acute and primary care. He is highly familiar with the diagnosis and treatment of multiple disease states and health concerns.

 Dr Charalampia V. Geladari, MD is a senior Internal Medicine Resident and a Research Fellow at the Hypertension and Cardiovascular Prevention Clinic, Fourth Department of Internal Medicine at Evangelismos General Hospital, in Athens, Greece, and also at the Hypertension and Vascular Medicine Clinic, of the Veterans Affairs Medical Center, in Washington, DC, USA. She has previously been a postdoctoral cardiovascular fellow at Beth Israel Deaconess Medical Center, Harvard University, Boston Massachusetts.

Blurb

This book is a valuable tool to assist both cardiovascular physicians and scientists learning the intricacies of hypertension research and its milestone studies. All major hypertension trials have been reviewed in this book in chronological order with extensive discussion of the study population, study design, and outcomes and with a special focus on what knowledge they offered, their strengths and weaknesses, statistical errors, impact on international guidelines and unmet needs. Importantly, the book also offers physicians and young scientists with basic knowledge regarding medical biostatistics. It is of critical importance for a scientist involved in the field to understand deeply the process of analysing medical data. Moreover, the accurate interpretation of the results is central for applying evidence-based medicine in everyday clinical practice.

Management of Hypertension: Current Practice and the Application of Landmark Trials is a critical tool to assist in the education of physicians and researchers in the field, providing a separate section on pioneer researchers in hypertension and urging readers to become bright exemplars for scientists wishing to pursue a career in academic medicine and hypertension research.