Mammalian Host Defense Peptides

ISBN-13: 9780521822206 / Angielski / Twarda / 2004 / 408 str.

Dierdre A. Devine; Deirdre A. Devine; Robert E. W. Hancock

Opis

This book draws together contributions from many leading scientists and reviews the most significant recent advances in the development of mammalian host defense peptides. These short, cationic single gene products have been isolated from a vast array of higher and lower organisms, and the conservation of function across so many species is an indication of their importance. Antimicrobial peptides are also the only new class of antimicrobial agent discovered in recent years, and there is interest in them as alternatives to conventional antibiotics.

Spis treści

1. Overview: antimicrobial peptides, as seen from a rear-view mirror R. I. Lehrer; 2. Cationic antimicrobial peptides in regulation of commensal and pathogenic microbial populations D. A. Devine; 3. Multiple functions of antimicrobial peptides in host immunity D. Yang and J. J. Oppenheim; 4. Therapeutic potential and applications of innate immunity peptides T. J. Falla and L. Zhang; 5. Mammalian β−Defensins in mucosal defence G. Diamond, D. Laube and M. Klein-Patel; 6. Biology and expression of the human cathelicidin LL-37 G. Gudmundsson and B. Agerberth; 7. Antimicrobial peptides of the alimentary tract of mammals C. Bevins and T. Ganz; 8. Antimicrobial peptides suppress microbial infections and sepsis in animal models K. A. Brogden, M. Ackermann, J. Zabner and M. J. Welsh; 9. Bacterial structure and physiology: influence on susceptibility to antimicrobial peptides R. E. W. Hancock; 9. The antifungal mechanisms of antimicrobial peptides E. J. Helmerhorst and F. G. Oppenheim; 10. Antimicrobial peptides from platelets in defence against cardiovascular infections M. R. Yeaman; 11. Mechanisms of bacterial resistance to antimicrobial peptides R. Tamayo, A. C. Portillo and J. S. Gunn; 12. Roles of antimicrobial peptides in pulmonary disease R. Bals.