1. Epidemiology and surveillance evidence2. Multimodality Imaging assessment of Malignant Pleural Mesothelioma3. Surgery of Malignant Pleural Mesothelioma4. Diagnostic pathology of Malignant Pleural Mesothelioma: cytological, histological, immunohistochemical features5. Molecular mechanisms in the pathogenesis of Malignant Pleural Mesothelioma: predictive and prognostic factors6. The treatment of Malignant Pleural Mesothelioma: from the current standard to novel possible therapeutic strategies7. Future directions in Malignant Pleural Mesothelioma: an overview of the expert opinion