Malignant Lymphomas Other Than Hodgkin's Disease: Histology - Cytology - Ultrastructure - Immunology

ISBN-13: 9783642810947 / Angielski / Miękka / 2012 / 836 str.

Karl Lennert

Opis

A.G. STANSFELD, and J.A.M. VAN UNNIK. In joint discussions in 1974, the Club worked out a new terminology that was acceptable to all members and will hopefully be acceptable to other pathologists. Since then, it has been called the Kiel Classification. We are also pleased that the clinicians belonging to the Kiel Lymphoma Study Group-foremost A. STACHER and G. BRITTINGER have been able to present preliminary data on the clinical relevance of the new classification. Finally, our optimism was fortified by the findings of R.J. LUKES and R.D. COLLINS, which largely concur with ours in both concept and practical significance. This book is divided into six main sections. First, there is a chapter on normal cytology that supplements and, in some respects, revises the presentation given in Part A of this Handbook (1961). H.K. MULLER-HERMELINK played a major role in the writing of the first chapter. The second chapter is a brief description of the light-microscopic techniques that are used in our laboratories and have proved to be suitable for a precise diagnosis of lymph-node diseases."

Spis treści

One The Cytologic, Histologic, and Functional Bases for a Modern Classification of Lymphomas.- I. Lymphocytes.- A. A New Understanding of Lymphocyte Physiology.- 1. Lymphocytes Are Not Obligate End Cells.- 2. Lymphocytes Are a Heterogeneous Group of Cells with Different Origins and Functions.- 3. Lymphocytes Are Destined to Migrate.- B. Identification of B- and T-Lymphocytes.- 1. Functional Identification of Human T-Lymphocytes.- 2. Functional Identification of Human B-Lymphocytes.- 3. Lymphocytes of Cell-Mediated, Antibody-Dependent Cytotoxicity (K-cells).- C. Cooperation of B- and T-Lymphocytes.- D. Derivation of Lymphocytes from the Hemopoietic Stem Cell.- II. Immunoblasts (Basophilic Stem Cells).- III. Plasma Cells.- Addendum: The So-Called T-Associated Plasma Cell.- IV. Histomorphology of the B-Cell Region.- A. Cytology of Germinal Centers.- B. Phases of Germinal-Center Development.- C. Kinetics of Germinal-Center Cells.- D. The Function of Germinal Centers.- V. Histomorphology of the T-Cell Region.- VI. Histochemistry of B- and T-Cell Regions.- VII. Stationary Elements of the Lymph Node.- A. Reticulum Cells.- 1. Histiocytic Reticulum Cell.- Addendum: Epithelioid Cell.- 2. Fibroblastic Reticulum Cell (“Dictyocyte”).- 3. Dendritic Reticulum Cell (Long-Branching Nonphagocytosing Reticulum Cell).- 4. Interdigitating Reticulum Cell.- B. Sinus Endothelial Cells.- 1. Endothelial Cells of the Marginal Sinus.- 2. Endothelial Cells of the Intermediate and Medullary Sinuses.- C. Mast Cells.- Two Methodologic Prerequisites for a Differential Diagnosis of Lymphomas.- Appendix: Some Stainings and Cytochemical Reactions Used in Our Laboratories.- Three Classification of Non-Hodgkin’s Lymphomas.- I. Historical Review of the Classifications of Lymphomas.- II. Some Ideas for a Modern Lymphoma Classification.- III. A Simplified Cellular Scheme as a Basis for a Modern Classification of Lymphomas.- IV. The Kiel Classification and Its Clinical Relevance.- V. Incidence of the Different Types of Lymphoma in our Material.- Four Histopathology and Diagnosis of Non-Hodgkin’s Lymphomas.- I. Malignant Lymphomas of Low-Grade Malignancy.- A. Malignant Lymphoma, Lymphocytic.- 1. Chronic Lymphocytic Leukemia, B-Cell Type (B-CLL).- Addenda: a) The Prolymphocytic Variant of B-CLL.- b) Is There a Nonleukemic Lymphoma of the CLL Type?.- 2. Chronic Lymphocytic Leukemia, T-Cell Type (T-CLL).- 3. Hairy-Cell Leukemia (HCL).- Addendum: Is There a Nonleukemic Lymphoma of the HCL Type?.- 4. Mycosis Fungoides (M.F.).- Addendum: Sézary’s Syndrome, a Leukemic Variant of Mycosis Fungoides.- 5. Malignant Lymphoma, Lymphocytic, T-Zone Type (T-Zone Lymphoma).- B. Lymphomas of Immunoglobulin-Secreting Cells.- 1. Malignant Lymphoma, Lymphoplasmacytic/Lymphoplasmacytoid (LP Immunocy- toma).- Addenda: a) The Leukemic Variants of LP Immunocytoma.- b) The Heavy-Chain Diseases.- 2. Malignant Lymphoma, Plasmacytic (Plasmacytoma).- Addenda: a) Metastases of Myeloma in Lymph Nodes.- b) The Leukemic Variant of Plasmacytoma: Plasma-Cell Leukemia.- C. Lymphomas of Germinal-Center Cells.- The Morphology of Centroblasts and Centrocytes.- 1. Malignant Lymphoma, Centrocytic (Centrocytoma).- Addendum: The Leukemic Variant of M.L. Centrocytic.- 2. Malignant Lymphoma, Centroblastic/Centrocytic.- Addendum: The Leukemic Variant of M.L. Centroblastic/Centrocytic.- II. Malignant Lymphomas of High-Grade Malignancy.- A. Malignant Lymphoma, Centroblastic.- 1. Primary Centroblastic Lymphoma.- 2. Secondary Centroblastic Lymphoma.- Addendum: The Leukemic Variant of M.L. Centroblastic.- B. Malignant Lymphoma, Lymphoblastic (Lymphoblastic Sarcoma, Including Acute Lymphoblastic Leukemia).- 1. B-Lymphoblastic Lymphoma.- a) M.L. Lymphoblastic, Burkitt Type.- b) B-Lymphoblastic Lymphomas Other than Burkitt Type.- 2. T-Lymphoblastic Lymphoma.- a) M.L. Lymphoblastic, Convoluted-Cell Type.- b) T-Lymphoblastic Lymphomas without Convoluted Nuclei.- 3. M.L. Lymphoblastic, Unclassified, Including Null-Lymphoblastic Lymphomas.- Addendum (to 1—3): The Leukemic Variants of Malignant Lymphoma, Lymphoblastic: Lymphoblastic Leukemias (ALL).- C. Malignant Lymphoma, Immunoblastic (Immunoblastic Sarcoma).- Addenda: a) The Leukemic Variant of M.L. Immunoblastic: Immunoblastic Leukemia.- b) Reticulosarcoma.- 1. Sarcomas of Histiocytic Reticulum Cells.- 2. Sarcomas of Fibroblastic Reticulum Cells.- 3. Sarcomas of Dendritic Reticulum Cells.- 4. Sarcomas of Interdigitating Reticulum Cells.- 5. Sarcomas of Sinus Endothelial Cells.- 6. Malignant Neoplasms of Monocytes and Their Derivatives.- Conclusions.- Five Ultrastructure of Non-Hodgkin’s Lymphomas.- Remarks on Methods.- I. Low-Grade Malignant Lymphomas.- A. Malignant Lymphoma, Lymphocytic.- 1. Chronic Lymphocytic Leukemia.- a) B-Type.- b) T-Type.- 2. Hairy-Cell Leukemia.- 3. Mycosis Fungoides and Sézary’s Syndrome.- a) Mycosis Fungoides.- b) Sézary’s Syndrome.- 4. T-Zone Lymphoma.- B. Malignant Lymphoma Lymphoplasmacytic/Lymphoplasmacytoid (LP immunocytoma).- C. Malignant Lymphomas of Germinal-Center Cells.- 1. Malignant Lymphoma, Centrocytic.- 2. Malignant Lymphoma, Centroblastic/Centrocytic.- II. High-Grade Malignant Lymphomas.- A. Malignant Lymphoma, Centroblastic.- B. Malignant Lymphoma, Lymphoblastic.- 1. Burkitt Type.- 2. Convoluted-Cell Type (Acid Phosphatase Type).- 3. T-Lymphoblastic Lymphoma without Convoluted Nuclei (Malignant Lymphoma of T-Associated Plasma Cells).- 4. Unclassified.- C. Malignant Lymphoma, Immunoblastic (Immunoblastic Sarcoma).- Addendum: Reticulosarcoma.- Conclusions.- Six The Immunologic and Immunochemical Basis for the Kiel Classification.- I. Immunochemical and Immunologic Methods and Markers and Their Significance for the Characterization of Lymphoid-Cell Populations.- A. Immunoglobulin Content of Tissue Extracts.- B. Demonstration of Monoclonality.- C. Surface Immunoglubulin (SIg).- D. Cytoplasmic Immunoglobulin (CIg).- E. IgG-Fc-Fragment Receptor (IgG-Fc Receptor).- F. Complement Receptor.- G. Mouse-Erythrocyte (E) Receptor.- H. Sheep-Erythrocyte (E) Receptor.- Addendum: Evaluation of Rosette Tests.- I. Human T-Associated Antigens.- 1. Human T-Lymphocyte Antigen (HTLA).- 2. Thymocyte-Specific Antigen (THYSA).- 3. Human Thymus/Leukemia-Associated Antigen (HTHY-L).- 4. CLL/Thymus Antigen (CLL-THYA).- J. Common-ALL Antigen.- K. Human B-Associated Antigens: Ia-Like Antigens.- L. Terminal Deoxynucleotidyl Transferase (Tdt).- M. Receptor for Hemagglutinin A from the Snail Helix Pomatia (HP).- II. Immunologic Findings and Their Relevance to the Classification of Non-Hodgkin’s Lymphomas.- A. Chronic Lymphocytic Leukemia (CLL).- B. Prolymphocytic Leukemia.- C. Hairy-Cell Leukemia (HCL).- D. Mycosis Fungoides.- E. Sezary’s Syndrome.- F. Malignant Lymphoma, Lymphocytic, T-Zone Type (T-Zone Lymphoma).- G. Malignant Lymphoma, Lymphoplasmacytic/Lymphoplasmacytoid (LP Immunocytoma).- H. Malignant Lymphoma, Plasmacytic (Plasmacytoma).- I. Malignant Lymphoma, Centrocytic.- J. Malignant Lymphoma, Centroblastic/Centrocytic.- K. Malignant Lymphoma, Centroblastic.- L. Lymphoblastic Lymphoma, Burkitt Type.- M. Lymphoblastic Lymphoma Other than the Burkitt Type.- N. Malignant Lymphoma, Immunoblastic.- Addendum: Reticulosarcoma.- Summary and Final Remarks.- References, Part One.- Parts Two, Three and Four.- Five.- Six.- Author Index.