Male-Mediated Developmental Toxicity

ISBN-13: 9781461357643 / Angielski / Miękka / 2012 / 406 str.

Andrew F. Olshan; Donald R. Mattison

Opis

The cause of many of the adverse reproductive outcomes and developmental diseases among offspring is not well understood. Most of the epidemiologic and experimental animal research has focused on the relationship between maternal exposures including medications, tobacco smoke, alcohol, infections, and occupation and the occurrence of spontaneous abortion, low birth weight, and birth defects. The potential role of paternal exposures has not been investigated as extensively despite long-standing animal research that demonstrates the induction of mutations in the male germ cell after exposure to certain agents and subsequent reproductive failure or early pregnancy loss. Given this relative lack of interest, acquisition of epidemiologic data and the development of a definitive model or mechanism for potential male-mediated effects has been hindered. However, recent laboratory and epidemiologic investigations have suggested that paternal exposures may be more important than previously suspected. This topic has been termed by some as "male-mediated developmental toxicity. " This is meant to refer to the effects of exposures and other factors relating to the male parent that result in toxicity to the conceptus and abnormal development. The developmental endpoints of interest can include fetal loss, congenital abnormalities, growth retardation, cancer, and neurobehavioral effects. These effects may operate through a variety of mechanisms including gene mutation, chromosomal aberrations, seminal fluid transfer of toxicants and epigenetic events.

Spis treści

Introduction; A.F. Olshan, D.R.Mattison. Concepts and Mechanisms: Methods and Concepts in Detecting Abnormal Reproductive Outcomes of Paternal Origin; A.J. Wyrobek. Laboratory Evidence: Specificlocus Mutation Tests in Germ Cells of the Mouse: An Assessment of the Screening Procedures and the Mutational Events Detected; J. Favor. Laboratory Evidence for Congenital Anomalies, Cancer and Neurobehavioral Outcomes: The Malemediated Developmental Toxicity of Cyclophosphamide; B.F. Hales, B. Robaire. Epidemiological Findings: Paternal Occupation and Birth Defects; A.F. Olshan, P.G. Schnitzer. Paternal Exposures and Pregnancy Outcome: Miscarriage, Stillbirth, Low Birth Weight, Preterm Delivery; D.A. Savitz. Risk Assessment and Policy Issues: Characteristics of Malemediated Teratogenesis; T. Nagao. Abstracts: Occupations of Fathers before Conception and the Risk of Testicular Cancer in Their Sons; J.A. Knight, et al. Breakout Groups: Laboratory Research Methods in Malemediated Toxicity; M.D. Shelby. 33 additional articles. Index.