Male Fertility and Its Regulation

ISBN-13: 9789401086677 / Angielski / Miękka / 2012 / 496 str.

T. J. Lobl; E. S. Hafez

Opis

Uncontrolled population growth, a significant problem for many countries, depresses real living standards in all developing areas. As a corollary, un controlled population growth also stresses the ability to deliver adequate reproductive health care on both national and individual levels. To focus on this and related problems an International Congress to examine many aspects of male and female Reproductive Health Center Care was held on 10-15 October 1982 in Maui, Hawaii, USA. This volume is a result of the proceedings from the 'Symposium on Male Fertility and its Regulation' which was a part of the Reproductive Health Care Congress. The organizers of this symposium recognized the need to focus male reproductive understanding on contraceptive development. The ultimate objective was and still is to produce a variety of safe and effective male contraceptives similar to that accomplished in the female. Speakers were invited to review the state of the art in several areas related to male contra ception, reproductive toxicity and reproductive biology. The abstracts of these sessions were published as a special issue of Archives of Andrology (Vol. 9, No.1, August, 1982). Subsequently, this volume was assembled from key papers presented at the Symposium. Additionally, invited man uscripts from leaders in specific areas were solicited to provide additional range to the topics covered."

Spis treści

I. Non-Hormonal Antifertility Agents.- 1 3-lndazole-carboxylic acids as male antifertility agents.- 2 Chemotherapeutic agents and male reproduction.- 3 Effects of 5-thio-D-glucose on male fertility.- II. Drugs and Male Fertility.- 4 Therapeutic drug effects on male reproductive function.- 5 Reversible male infertility induced by sulphasalazine.- 6 Effects of illicit drugs on male reproduction.- 7 Effects of abused substances on male reproductive development.- III. Gossypol.- 8 Gossypol chemistry and plant distribution.- 9 Toxicological effects of gossypol.- 10 Biochemical and nutritional considerations of gossypol intake.- 11 Gossypol contraception and mechanism of action.- 12 Gossypol inhibition of boar spermatozoal enzymes.- 13 Gossypol modulation of testosterone secretion and metabolism.- 14 Gossypol inhibition of LDH-X.- IV. Environmental Agents Affecting Fertility.- 15 Environmental chemical effects on testicular function.- 16 Consequences to the progeny of paternal drug exposure.- 17 Animal tests employed to assess the effects of drugs and chemicals on reproduction.- 18 Effects of phenoxy acid herbicides and TCDD on male reproduction.- 19Human spermatogenesis and fertility following exposure to dibromochloropropane (DBCP).- V. Hormones and Hormone Antagonists.- 20 LHRH and its analogues: potential for male contraception and for therapy of androgen- dependent syndromes.- 21 Direct regulation of Leydig cell functions by neuropeptides.- 22 Non-steroidal inhibitors of androgen transport and metabolism.- 23 Danazol plus testosterone enanthate in male langur monkey.- 24 Inhibin and male contraception.- VI. Blood-Testicular and Epididymal Barriers.- 25 The blood-epididymis barrier.- 26 The tenacity of the blood-testis and blood- epididymal barriers.- VII. Sperm Physiology.- 27 Sperm maturation and transport.- 28 Ionic mechanisms of sperm motility initiation.- 29 Reproductive effects of sperm surface antibodies.- 30 Sperm calcium homeostasis during maturation.- 31 The zona-free hamster egg sperm penetration assay.