1 A Summary of Recent Updates on the Genetic Determinants of Depression 2 Epigenetics of Major Depressive Disorder 3 Brain Structural Abnormalities of Major Depressive Disorder 4 Cognitive Deficits in Major Depression: From Mechanisms to Management 5 Neuroendocrine Alterations in Major Depressive Disorder 6 Inflammatory Abnormalities in Major Depressive Disorder 7 Psychiatric Comorbidity in Major Depressive Disorder 8 Pharmacological Treatment of Major Depressive Disorder 9 Neurocircuitry-Based Treatments for Major Depressive Disorder 10 Pharmacological and Nonpharmacological Treatment Effects on Functional Outcomes in Major Depressive Disorder 11 Internet-Based/Technology-Based Interventions in Major Depressive Disorder 12 Dysregulation of the Glutamatergic System in Major Depressive Disorder 13 Glutamate Modulators in Major Depressive Disorder 14 Depression in Children and Adolescents