Magnetic Resonance Imaging: Methods and Biologic Applications

ISBN-13: 9781627038126 / Angielski / Miękka / 2014 / 447 str.

Pottumarthi V. Prasad

Opis

Leading experts in the use of MRI explain its basic principles and demonstrate its power to understand biological processes with numerous cutting-edge applications. To illustrate its capability to reveal exquisite anatomical detail, the authors discuss MRI applications to developmental biology, mouse phenotyping, and fiber architecture. MRI can also provide information about organ and tissue function based on endogenous cantrast mechanisms. Examples of brain, kidney, and cardiac function are included, as well as applications to neuro and tumor pathophysiology. In addition, the volume demonstrates the use of exogenous contrast material in functional assessment of the lung, noninvasive evaluation of tissue pH, the imaging of metabolic activity or gene expression that occur on a molecular level, and cellular labeling using superparamagnetic iron oxide contrast agents.

Recenzje

From the reviews:

"Magnetic Resonance Imaging: Methods and Biologic Applications offers something of interest for MRI novices as well as more experience practitioners. The language is clear and easy to read, and the diagrams ... are very helpful." (AuntMinnie.com, February, 2006)

"This book is one of a large series of books on Methods in Molecular Medicine, edited by John M. Walker with 28 contributors ... . The authors are distinguished, primary basic scientists in basic science departments or departments of cardiology or radiology. ... I believe this book would be valuable for departments that are about to use or are using MRI as a research tool ... and as an addition to department libraries dealing with this technique." (Joseph P. Whalen, Clinical Imaging, Vol. 30, 2006)

Spis treści

I. Introduction Introduction to Magnetic Resonance Imaging and Spectroscopy Pippa Storey Magnetic Resonance Microscopy: Concepts, Challenges, and State-of-the-Art Barjor Gimi II. Anatomy Magnetic Resonance Imaging of Embryonic and Fetal Development in Model Systems Eric T. Ahrens, Mangala Srinivas, Saverio Capuano, Hyagriv N. Simhan, and Gerald P. Schatten Mouse Morphological Phenotyping With Magnetic Resonance Imaging X. Josette Chen Magnetic Resonance Microscopy of Mouse Brain Development Susumu Mori, Jiangyang Zhang, and Jeff W. M. Bulte III. Physiology Quantitative Perfusion Imaging Using Arterial Spin Labeling Donald S. Williams Physiology of Functional Magnetic Resonance Imaging: Energetics and Function Ikuhiro Kida and Fahmeed Hyder Functional Magnetic Resonance Imaging of the Kidney Pottumarthi V. Prasad Cardiac Magnetic Resonance Spectroscopy: A Window for Studying Physiology Michael Horn IV. Pathophysiology Application of Magnetic Resonance Imaging to Study Pathophysiology in Brain Disease Models Rick M. Dijkhuizen Magnetic Resonance Imaging of Tumor Physiology Arvind P. Pathak Magnetic Resonance Imaging in Preclinical Drug Development Matthew D. Silva and Sudeep Chandra V. Novel Contrast Agents and Mechanisms Hyperpolarized Gas and Oxygen-Enhanced Magnetic Resonance Imaging Vu M. Mai Tissue pH Measurement by Magnetic Resonance Spectroscopy and Imaging Natarajan Raghunand Biological Applications of Manganese-Enhanced Magnetic Resonance Imaging Robia G. Pautler Targeted Magnetic Resonance Imaging Contrast Agents Shelton D. Caruthers, Patrick M. Winter, Samuel A. Wickline, and Gregory M. Lanza Design and Characterization of Magnetic Resonance Imaging Gene Reporters Angelique Louie Intracellular Endosomal Magnetic Labeling of Cells Jeff W. M. Bulte Index

Blurb

Even as magnetic resonance imaging (MRI) has matured into an invaluable diagnostic tool, it has also become a key experimental tool in biological research, where it demonstrates special sensitivity to a plethora of physiological factors, as well as a capacity for use all the way from cellular suspensions to in vivo human studies. In Magnetic Resonance Imaging: Methods and Biologic Applications, leading experts in the use of MRI from both academia and industry explain its basic principles and demonstrate its power to understand biological processes with numerous cutting-edge applications. To illustrate its capability to reveal exquisite anatomical detail, the authors discuss MRI applications to developmental biology, mouse phenotyping, and fiber architecture. MRI can also provide information about organ and tissue function based on endogenous contrast mechanisms. Examples of brain, kidney, and cardiac function are included, as well as applications to neuro- and tumor pathophysiology. In addition, the volume demonstrates the use of exogenous contrast material in functional assessment of the lung, noninvasive evaluation of tissue pH, the imaging of metabolic activity or gene expression that occur on a molecular level, and cellular labeling using superparamagnetic iron oxide contrast agents.
Cutting-edge and user-friendly, Magnetic Resonance Imaging: Methods and Biologic Applications illuminates for biological scientists the basic principles of MRI and shows how it can be used successfully to solve important biological problems.