Magnesium and Its Alloys as Implant Materials

ISBN-13: 9781032654331 / Angielski / Miękka / 2023 / 194 str.

Mirco Peron;Filippo Berto;Jan Torgersen

Opis

Despite their tremendous potential, Mg and its alloys are not yet used in biomedical applications. This book aims to provide scientific insights into the challenges of the materials, and give an overview of the research regarding their mechanical properties, corrosion behaviour and biological performances. The authors intend to put the reader into the position to accurate discern the proper Mg-based material for his/her applications and to choose the proper improvement strategy to his/her cause. To this aim, the manuscript is structured as follow: in Section 2, the main challenges hampering the use of magnesium in biomedical applications and the common improvement strategies are listed. In Section 3, the most investigated Mg alloys are reported in separate sub-sections, detailing their mechanical properties, corrosion behaviour and biotoxicity. High-pure and ultra-high-pure Mg, Al-based Mg alloys, Zn-based Mg alloys, Ca-based alloys and RE-based Mg alloys have been considered. In Section 4, the alloys’ performances with respect to the challenges is summarized providing the reader with useful information and suggestions on the potentially most suited choice. Finally, in Section 5, an outlook portraying the authors’ opinion of the future development of the field will be provided. This book will allow biomedical engineers, surface scientists, material scientists, implant manufacturers and companies working on implant approval an overview of the state-of-the-art technologies adopted so far to overcome the drawbacks of Mg for biomedical applications. Particular emphasis is put on explaining the link between mechanical, corrosion and biocompatible properties of Mg and its alloys as well as their pros and cons. In doing so, the authors intend to put the reader into the position to accurate discern the proper Mg-based material for his/her applications and to choose the proper improvement strategy to his/her cause.

Despite their tremendous potential, Mg and its alloys are not yet used in biomedical applications. This book aims to provide scientific insights into the challenges of the materials, and give an overview of the research regarding the mechanical properties, corrosion behaviour and biological performances of these materials.

Spis treści

Chapter 1 Introduction

1. Introduction

References

Chapter 2 Challenges and Common Strategies

1. Introduction
2. Corrosion Mitigation Strategies

1. Impurities Removal
2. Alloying
3. Grain Size Modification

3. Mechanical Properties Tuning

1. Grain Refinement
2. Solid Solution Strengthening
3. Precipitation Hardening

4. Interplay among Mechanical Properties, Corrosion

Resistance and Biocompatibility

References

Chapter 3 Synopsis of Properties of Biocompatible Mg and Its Alloys

1. Introduction
2. High-Pure Magnesium

1. High-Pure Magnesium: Mechanical Properties
2. High-Pure Magnesium: Corrosion Resistance
3. High-Pure Magnesium: Biocompatibility

3. Aluminum-Based Alloys

1. AZ Alloys

1. AZ Alloys: Mechanical Properties
2. AZ Alloys: Corrosion Resistance
3. AZ Alloys: Biocompatibility

2. AM Alloys

1. AM Alloys: Mechanical Properties
2. AM Alloys: Corrosion Resistance
3. AM Alloys: Biocompatibility

3. Mg–Al–RE Alloys

1. Mg–Al–RE Alloys: Mechanical Properties
2. Mg–Al–RE Alloys: Corrosion

Resistance

3. Mg–Al–RE Alloys: Biocompatibility

4. Mg–Zn Alloys

1. Mg–Zn Binary Alloys

1. Mg–Zn Binary Alloys: Mechanical Properties
2. Mg–Zn Binary Alloys: Corrosion

Resistance

3. Mg–Zn Binary Alloys: Biocompatibility

2. Mg–Zn–Zr Alloys

1. Mg–Zn–Zr Alloys: Mechanical Properties
2. Mg–Zn–Zr Alloys: Corrosion

Resistance

3. Mg–Zn–Zr Alloys: Biocompatibility

3. Mg–Zn–Ca Alloys

1. Mg–Zn–Ca Alloys: Mechanical Properties
2. Mg–Zn–Ca Alloys: Corrosion

Resistance

3. Mg–Zn–Ca Alloys: Biocompatibility

4. Mg–Zn–Ca BMGs

1. Mg–Zn–Ca BMGs: Mechanical Properties
2. Mg–Zn–Ca BMGs: Corrosion Resistance
3. Mg–Zn–Ca BMGs: Biocompatibility

5. Mg–Zn–Mn Alloys

1. Mg–Zn–Mn Alloys: Mechanical Properties
2. Mg–Zn–Mn Alloys: Corrosion

Resistance

3. Mg–Zn–Mn Alloys: Biocompatibility

6. Mg–Zn–RE Alloys

1. Mg–Zn–RE Alloys: Mechanical Properties
2. Mg–Zn–RE Alloys: Corrosion

Resistance

3. Mg–Zn–RE Alloys: Biocompatibility

　

5. Mg–Ca Alloys

1. Mg–Ca Alloys: Mechanical Properties
2. Mg–Ca Alloys: Corrosion Resistance
3. Mg–Ca Alloys: Biocompatibility

6. Mg–RE Alloys

1. Mg–RE Alloys: Mechanical Properties
2. Mg–RE Alloys: Corrosion Resistance
3. Mg–RE Alloys: Biocompatibility

References

Chapter 4 Tackling the Challenges

1. Introduction
2. Radar Chart: An Easy Tool to Compare Corrosion, Mechanical and Biological Performances

References

Chapter 5 Outlook

Reference

Appendix A: Corrosion

Appendix B: In Vitro Biocompatibility Assessment

Index

O autorze

Mirco Peron earned his degree in mechanical engineering (summa cum laude)

in 2015 from the University of Padova, where his thesis evaluated the fatigue

damage and stiffness evolution in composite laminates. He is currently a PhD

student at Norwegian University of Science and Technology (NTNU), Trondheim.

His PhD topic deals with the optimization of mechanical and corrosion

properties of magnesium and its alloys for biomedical applications, with particular

reference to the corrosion-assisted cracking phenomena.

Filippo Berto is Chair of Structural Integrity at the Norwegian University of

Science and Technology in Norway. He is in charge of the Mechanical and

Material Characterization Lab in the Department of Mechanical and Industrial

Engineering. He is author of more than 500 technical papers, mainly

oriented to materials science engineering, the brittle failure of different materials,

notch effect, the application of the finite element method to the structural

analysis, the mechanical behavior of metallic materials, the fatigue performance

of notched components as well as the reliability of welded, bolted and

bonded joints. Since 2003, he has been working on different aspects of the

structural integrity discipline, by mainly focusing attention on problems

related to the static and fatigue assessment of engineering materials with particular

attention to biomedical and medical applications and materials.

Jan Torgersen is Professor of mechanical engineering at NTNU, Trondheim.

He received his PhD from Vienna University of Technology, where he worked

on high-resolution laser microfabrication of hydrogels for tissue engineering.

He was pioneering in the work of processing hydrogel formulations at micron

scale resolution in vivo, in the presence of living cells and whole organisms.

He received a postdoctoral fellowship to work on a nanoscale vapor deposition

technique called atomic layer deposition, allowing conformal coating of

thermally fragile and nanostructured substrates with atomically thin layers of

a wide range of materials. He contributed to the development of a selflimiting

deposition process for high-k materials for Dynamic Random Access

Memory (DRAM) applications. His current research interests are micro- and

nanofabrication as well as surface functionalization, with particular focus on

biomedical applications.