Lymphocyte Trafficking in Health and Disease

ISBN-13: 9783764373085 / Angielski / Twarda / 2006 / 253 str.

Raffaele Badolato; Silvano Sozzani

Opis

Since the discovery of chemokines and of chemokine receptors it has become evident that expression of chemokines at the site of inflammation may regulate the composition of cellular infiltrate, thereby directing the type of immune response. Recently, the molecular characterization of inherited disorders of immune system, (e.g., Wiskott-Aldrich syndrome, WHIM syndrome, leukocyte adhesion deficiency), which are characterized by cytoskeleton/adhesion defects or by altered response of chemokine receptors has contributed to clarifying the key players of immune response in normal physiology and in disease. This book, which deals with the description of the role of chemokines in immune response and underlines potential targets of therapeutical intervention, offers a series of contributions of the most challenging aspects of lymphocyte migration in homeostasis and in disease.

Spis treści

Lymphocyte trafficking: from immunology paradigms to disease mechanisms.- Biology of chemokines.- Lymphocyte-endothelial cell interaction.- Chemokine receptor expression in effector and memory T cell subsets.- Migration of dendritic cell subsets.- Migration of NK cells.- Lymphocyte trafficking and chemokine receptors during pulmonary disease.- Lymphocyte migration to the brain.- Lymphocyte migration to the kidney.- Lymphocyte migration to pancreatic islets.- Controlling leukocyte trafficking in disease.- Leukocyte adhesion deficiency .- Wiskott-Aldrich syndrome as a model of cytoskeleton defects .- From CXCR4 mutations to WHIM syndrome