Lupus: Molecular and Cellular Pathogenesis

ISBN-13: 9780896035560 / Angielski / Twarda / 1999 / 709 str.

Gary M. Kammer; George C. Tsokos

Opis

Leading basic and clinical investigators from around the world summarize the most recent research on the molecular and cellular origins of lupus. Their cutting-edge articles review the mechanisms underlying abnormal immunity and introduce the powerful new concept that a disorder of multiple genes underlies the abnormal immune response, leading directly to the development of lupus. This pathophysiology is shown to involve a wide variety of cell types, including T cells, B cells, natural killer cells, macrophages/monocytes, and endothelial cells. Over time, the resulting long-term inflammation causes irreversible cell destruction and, ultimately, organ failure. Lupus: Molecular and Cellular Pathogenesis is a masterful new synthesis of all the new knowledge emerging today about lupus. Its new perspectives will sharpen the focus of research and ultimately lead to better and more effective treatment.

Recenzje

"This effort represents a comprehensive and authoritative coverage of work on lupus. It is up to date in that the latest developments in the field are provided (e.g., the role of Fas and apoptosis in disease management). All workers in this area will find this a valuable resource. It also represents a worthwhile addition to medical libraries..." -4 Stars, Doody's Health Sciences Book Review Journal

"Firstly, the references quoted in the various chapters are well poised, with a mix of historical ones and very recent ones. Secondly, the authors were asked to keep in mind four issues while writing: their working hypothesis, the relationship between the hypothesis and the advancement of understanding of lupus pathogenesis, how novel information allows new insights in the field and where to direct research in the next 5 years...I strongly recommend reading this book. It has the major merit of presenting in a coordinated fashion many new findings on a disease that remains largely mysterious. This book has the potential to encourage cross-fertilization among researchers interested in the field of autoimmunity, and provides a valuable tool for newcomers to get a sense of the daunting problems that remain to be solved in order to better understand the regulation and dysregulation of the immune system." -Journal of Investigative Dermatology

Spis treści

Lupus: The Clinical Entity, Evelyn V. Hess. The Vascular Endothelium: A New Actor in The Pathogenesis of Vascular Injury in Systemic Lupus Erythematosus, Bruce N. Cronstein, Allison Reiss, and Sandeep Malhotra. Nitric Oxide in Systemic Lupus Erythematosus: Implications for Immunity and Inflammation, H. Michael Belmont, Ashok R. Amin, and Steven B. Abramson. Molecular Mimicry, Altered Apoptosis, and Immunomodulation as Mechanisms of Viral Pathogenesis in Systemic Lupus Erythematosus, Andras Perl and Katalin Banki. Clustering and Proteolytic Cleavage of Autoantigens in Surface Blebs of Apoptotic Cells: Implications for Pathogenesis of SLE, Antony Rosen and Livia A. Casciola-Rosen. Immune Effects of Bacterial DNA and Their Possible Role in the Pathogenesis of Lupus, Rebecca S. Tuetken, Ae-Kyung Yi, and Arthur M. Krieg. Genetics of Systemic Lupus Erythematosus, Pércio S. Gulko and Robert J. Winchester. Genetic Insights into Murine Lupus, Chandra Mohan, Laurence Morel, and Edward K. Wakeland. Murine Graft-vs-Host Disease: Relevance to Human Lupus Immunopathogenesis and Therapy, Andrei Shustov, Violetta Rus, Phuong Nguyen, and Charles S. Via. Lessons From Knockout and Transgenic Lupus-Prone Mice, Stanford L. Peng and Joe Craft. B Cells in Systemic Lupus Erythematosus, Stamatis-Nick C. Liossis and George C. Tsokos. Mechanisms of the Pathogenic Autoimmune Response in Lupus: From Mouse Models to Human Disease, Syamal K. Datta. T-Cell Autoimmunity in Lupus: Ignorance, Anergy, and Activation, Mark J. Mamula. T-, B-, and Natural Killer Cell Dysfunction in Murine Systemic Lupus Erythematosis Models, Philip L. Cohen. Mechanisms of T-Helper Cell Activation and Function in Systemic Lupus Erythematosus, Mary K. Crow. A Genetic Mechanism Underlying Deficient Type I Protein Kinase A Activity in Systemic Lupus Erythematosus T Lymphocytes, Islam U. Khan, Dama Laxminarayana, and Gary M. Kammer. Impaired DNA Methylation in Lupus T Cells, Jeannine M. Scott and Bruce C. Richardson.Impaired Non-Antigen-Specific T-Cell Cytolytic Activity in SLE, William Stohl. Natural Killer Cells and CD8+ T Cells in the Downregulation of Antibody Production in Healthy Subjects and SLE: A Role for Transforming Growth Factor-b and Interleukin-2, David A. Horwitz, J. Dixon Gray, Katzuo Ohtsuka, Bricia Toro, Mary M. Stimmler, and Lillie Hsu. Cytokines in the Immunopathogenesis of Lupus, Barry S. Handwerger, Irina Luzina, Ludmila da Silva, Catherine E. Storrer, and Charles S. Via. Cytokine Gene Expression in Human Systemic Lupus Erythematosus, Motoko Honda and Mariana Linker-Israeli. Balance Between Type 1 and Type 2 Cytokine-Secreting Cells: Impact on Disease Activity in Systemic Lupus Erythematosus, Daniela Verthelyi and Dennis M. Klinman. Autoantibodies as a Source of Peptides That Regulate Autoantibody Production, Bevra H. Hahn, Fanny M. Ebling, Betty P. Tsao, and Ram R. Singh. Autoantibodies to Intracellular Antigens in Systemic Lupus Erythematosus Patients That Bind and Penetrate Cells, Morris Reichlin. Pathogenesis of Autoantibody Production and Glomerulonephritis in Pristane-Treated Mice: An Inducible Model of SLE, Minoru Satoh, Hanno B. Richards, and Westley H. Reeves. Anti-DNA Antibodies: Markers of the Pathogenesis of Systemic Lupus Erythematosus, David S. Pisetsky. The Anti-DNA Response in Lupus: Structure, Initiation, and Pathogenesis, Jeff Newman and Betty Diamond. Glomerular Binding Antibodies in Systemic Lupus Erythematosus, Gary S. Gilkeson. The Antiphospholipid Syndrome: Mechanisms of Autoantibody-Mediated Thrombosis, Robert A. S. Roubey. Autoimmune-Associated Congenital Heart Block: Bringing Bedside Challenges to the Bench, Jill P. Buyon. Role of Calreticulin Autoimmunity in the Pathogenesis of Photosensitive Cutaneous Lupus Erythematosus, Tho Q. Nguyen, Doina Racila, and Richard D. Sontheimer. Complement System and Systemic Lupus Erythematosus, John P. Atkinson and Jürg A. Schifferli. Type One Complement Receptor and Human SLE, Daniel J.