Lung Cancer: Volume 2: Diagnostic and Therapeutic Methods and Reviews

ISBN-13: 9781489944191 / Angielski / Miękka / 2013 / 816 str.

Barbara Driscoll

Opis

This work, Lung Cancer, Volume 2: Diagnostic and Therapeutic Methods and Reviews, in the Methods in Molecular Medicine series presents an overview of the current status of those methods useful in the diagnosis and tre- ment of lung cancer both as it exists in the clinic and as it is being revoluti- ized in the laboratory. The book is intended to serve as a resource for researchers wishing to increase their knowledge of current and cutting edge technologies, in order that their investigations into neoplasms of the lung may benefit from this enriched diversity of techniques and approaches. Owing to the complex nature of the disease and the variety of methods available to analyze and attack it, no volume attempting to define diagnostic and therapeutic approaches to lung cancer can ever be complete. The sheer number of investigators involved in lung cancer research guarantees that some aspect will be inadvertently excluded. However, I hope that the range of techniques included herein will serve to open up new avenues of investigation for both the novice and experienced researcher."

Recenzje

"This is a good compilation of scientific information on lung cancer...it serves as a useful resource for scientists involved in lung cancer." -Doody's Health Sciences Book Review Journal

"The strongest part of the book is the detailed description of the different molecular techniques for marker analyses, which will be of great value for the lung cancer scientists working in basic science ant translational lung cancer research." -Annals of Oncology

Spis treści

Part I. Introduction Molecular and Genetic Aspects of Lung Cancer William N. Rom and Kam-Meng Tchou-Wong Part II. Detection of Altered Tumor Markers in Clinical Samples for Diagnosis and Prognosis A. Molecular Methods for Prognostic Detection of Altered Tumor Markers: Clinical Implications Molecular Alterations in Lung Cancer: Impact on Prognosis Takashi Kijima, Gautam Maulik, and Ravi Salgia Cellular Predictive Factors of Drug Resistance in Non-Small Cell Lung Carcinomas Manfred Volm, Reet Koomägi, and Werner Rittgen Clinical Implications of p53 Mutations in Lung Cancer Barbara G. Campling and Wafik S. El-Deiry An Epidemiologic and Clinicopathologic Overview of AIDS-Associated Pulmonary Kaposi's Sarcoma David M. Aboulafia Myeloperoxidase Promoter Region Polymorphism and Lung Cancer Risk Xifeng Wu, Matthew B. Schabath, and Margaret R. Spitz Clinical Utility of Tumor Markers in the Management of Non-Small Cell Lung Cancer Dennis E. Niewoehner and Jeffrey B. Rubins B. Molecular Methods for Prognostic Detection of Altered Lung Tumor Markers in Clinical Samples I. DNA-Based Analysis. Detection of Chromosomal Aberrations in Lung Tissue and Peripheral Blood Lymphocytes Using Interphase Fluorescence In Situ Hybridization (FISH) Randa A. El-Zein and Sherif Z. Abdel-Rahman In Situ Analysis of Telomerase RNA Gene Expression as a Marker for Tumor Progression W. Nicol Keith A High-Throughput Methodology for Identifying Molecular Targets Overexpressed in Lung Cancers Tongtong Wang and Steven G. Reed Expression Profiling of Lung Cancer Based on Suppression Subtraction Hybridization (SSH) Simone Petersen and Iver Petersen Comparative Genomic Hybridization of Human Lung Cancer Iver Petersen Sensitive Assays for Detection of Lung Cancer: MolecularMarkers in Blood Samples Marcia V. Fournier, Katherine J. Martin, Edgard Graner, and Arthur B. Pardee Fluorescent Microsatellite Analysis in Bronchial Lavage as a Potential Diagnostic Tool for Lung Cancer John K. Field and Triantafillos Liloglou Southern Blotting of Genomic DNA from Lung and Its Tumors: Application to Analysis of Allele Loss on Chromosome 11p15.5 Diana M. Pitterle and Gerold Bepler Assessment of Insulin-Like Growth Factors and Mutagen Sensitivity as Predictors of Lung Cancer Risk Xifeng Wu, He Yu, Nimisha Makan, and Margaret R. Spitz II. PCR-Based Analyses. Comparative Multiplex PCR and Allele-Specific Expression Analysis in Human Lung Cancer: Tools to Facilitate Target Identification Jim Heighway, Daniel Betticher, Teresa Knapp, and Paul Hoban Detection of K-ras Point Mutations in Sputum from Patients with Adenocarcinoma of the Lung by Point-EXACCT Veerle A. M. C. Somers and Frederick B. J. M. Thunnissen Detection of K-ras and p53 Mutations by 'Mutant-Enriched' PCR-RFLP Marcus Schuermann Detection of Small Cell Lung Cancer by RT-PCR for Neuropeptides, Neuropeptide Receptors, or a Splice Variant of the Neuron Restrictive Silencer Factor Judy M. Coulson, Samreen I. Ahmed, John P. Quinn, and Penella J. Woll III. Immunohistochemical Analyses Utilization of Thyroid Transcription Factor-1 Immunostaining in the Diagnosis of Lung Tumors Nelson G. Ordóñez Molecular Biologic Substaining of Stage I NSCLC Through Immunohistochemistry Performed on Formalin-Fixed, Paraffin-Embedded Tissue Mary-Beth Moore Joshi, Thomas A. D'Amico, and David H. Harpole, Jr A Sensitive Immunofluorescence Assay for Detection of p53 Protein in the Sputum Zumei Feng, Defa Tian, and Radoslav Goldman SPR1: An Early Molecular Marker for Bronchial Carcinogenesis Derick Lau, Linlang Guo, Andrew

Blurb

Molecular-based laboratory methods can help significantly in the diagnosis and treatment of lung cancer, a leading cause of death worldwide. In Lung Cancer, Volume 2: Diagnostic and Therapeutic Methods and Reviews, leading physicians, scientists, and noted researchers describe step-by-step techniques for lung cancer diagnosis based on the molecular analysis of clinical samples. These experts review currently accepted treatments and outline a variety of novel therapies, including treatments based on gene therapy, immunotherapy, and chemoprevention, and show how these newly improved techniques can give a better appreciation of the prognosis associated with the particular mutation uncovered by the technique. These methods use a variety of molecular techniques, including the manipulation of gene expression and the alteration of immune status, to combat lung cancer. A companion volume, Lung Cancer, Volume 1: Molecular Pathology Methods and Reviews, illuminates the etiology of lung cancer and provides reliable techniques for detecting the responsible genetic mutations at the cellular, DNA, and protein levels.
Comprehensive and informative, Lung Cancer, Volume 2: Diagnostic and Therapeutic Methods and Reviews illuminates how molecular approaches can and are being applied to the diagnosis of lung cancer. Together, these two volumes constitute an unprecedented resource for those who wish to better understand how this disease is being diagnosed and treated, and what novel techniques may be available to improve both processes.