Liver Pathophysiology: Therapies and Antioxidants

ISBN-13: 9780128042748 / Angielski / Twarda / 2017 / 914 str.

Pablo Muriel

Opis

Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies.

• Presents the most recent advances in hepatology, with a special focus on the role of oxidative stress in liver injury.
• Provides in vivo and in vitro models to study human liver pathology.
• Explains the beneficial effects of antioxidants on liver diseases.
• Contains the most recent and modern treatments of hepatic pathologies, including, but not limited to, stem cells repopulation, gene therapy and liver transplantation.

Spis treści

Section I. Introduction1. The Liver: General Aspects and Epidemiology2. Structure and Ultrastructure of the Normal and Diseased Liver

Section II. Liver Pathophysiology3. Hepatic Apoptosis and Necrosis: Mechanisms and Clinical Relevance4. Autoimmune Hepatitis5. Pathogenesis of Idiosyncratic Drug Induced Liver Injury6. Acetaminophen7. Liver Regeneration8. Nitric Oxide in Liver Ischemia-Reperfusion Injury9. The Immune System and Viral Hepatitis10. The Pathophysiology of Alcoholic Liver Disease11. Cytokines in Steatohepatitis12. Redox Signaling in NASH13. Amebic Liver Abscess14. Role of Cytokines and Reactive Oxygen Species in the Amebic Liver Abscess Produced by Entamoeba histolytica15. Epigenetics in Liver Disease: Involvement of Oxidative Stress16. Role of Oxidative and Nitrosative Stress in Hepatic Fibrosis17. Oxidative and Nitrosative Stress in Chronic Cholestasis18. Cholestasis, Contraceptives, and Free Radicals19. Is Human Cirrhosis a Reversible Disease?20. Obesity and Hepatocellular Carcinoma21. Oxidative Stress as a Mechanism for Hepatocellular Carcinoma22. Nuclear Factor-Kappa B Actions During the Development of Hepatocellular Carcinoma23. The Role of Senescence in Hepatic Diseases24. Exercise, Liver Steatosis, and Free Radicals25. The Metabolic Syndrome, Oxidative Stress, and the Liver26. Liver Diseases in the Elderly27. Cytokines in Hepatic Injury28. Nrf2: A Key Regulator of Redox Signaling in Liver Diseases29. Redox Regulation by HGF/c-Met in Liver Disease

Section III. Liver Metabolism30. Hepatic Metabolism in Liver Health and Disease31. Cytochrome P450 and Oxidative Stress in the Liver32. Drug Hepatic Clearance in Spinal Cord Injury

Section IV. Cirrhosis and Its Complications33. Complications of Cirrhosis: Introduction34. Portal Hypertension-Molecular Mechanisms35. Gastroesophageal Varices36. Ascites37. Reactive Nitrogen and Oxygen Species in Hepatic Encephalopathy38. Hepatorenal Syndrome39. Hepatopulmonary Syndrome and Portopulmonary Hypertension

Section V. Methods in Liver Disease40. Experimental Models of Liver Damage Mediated by Oxidative Stress41. Monitoring of Liver Fibrogenesis and Biochemical Diagnosis of Fibrosis42. In Vitro Models of HCC

Section VI. Therapies in Liver Disease43. The Liver, Oxidative Stress, and Antioxidants44. Herbal Drugs on the Liver45. Silymarin for Liver Disease46. Naringenin and the Liver47. Antioxidant, Antiinflammatory, and Antifibrotic Properties of Quercetin in the Liver48. Coffee and the Liver49. Hepatoprotective Properties of Curcumin50. Retinoids in Liver Function51. Stevia as a Putative Hepatoprotector52. Are N-Acetylcysteine and Resveratrol Effective Treatments for Liver Disease?53. Does Nutrition Matter in Liver Disease?54. One-Carbon Metabolism in Liver Health and Disease55. Ursodeoxycholic Acid for the Treatment of Liver Diseases56. Current Treatment of Chronic Hepatitis C57. An Adenosine Derivative Compound as a Hepatoprotective Agent58. Nitric Oxide and the Liver59. Repopulation of Cirrhotic Liver by Hepatic Stem/Progenitor Cells: A Promising Strategy Alternative to Liver Transplantation60. Gene Therapy for Liver Disease61. Role of Oxidative Stress in Liver Transplantation

O autorze

Dr. Muriel PhD has research experience in the pathophysiology and pharmacology of liver diseases including necrosis, fibrosis and cholestasis; the role of cytokines in liver diseases; and oxidative stress and its relation to liver disease. He has published over 100 articles (original and reviews) in addition to 7 book chapters in the area of the liver and has also directed the thesis on dozens of postgraduate students in the same area over the last 30 years. The majority of his work has been in the Medicine and Pharmacology areas. He shows strong and growing citation counts from 2010-2017.