Liver Diseases and Hepatic Sinusoidal Cells

ISBN-13: 9784431680123 / Angielski / Miękka / 2013 / 348 str.

Kyuichi Tanikawa; Takato Ueno

Opis

Hepatic sinusoidal cells such as sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, and pit cells play an important role in hemodynamic and metabolic function and are involved in various liver diseases. The frequent involvement of sinusoidal cells in pathologic conditions is explained by the diverse actions of those cells, an understanding of which is essential to clinicians. Generously illustrated, this volume presents results of recent studies on hepatic sinusoidal cells in liver diseases, with an introduction to the structure and function of the various types of sinusoidal cells. The in-depth focus of the book is on the role of hepatic sinusoidal cells in relation to liver injury and regeneration, hepatic sinusoidal microcirculation, alcoholic liver diseases, hepatic fibrosis, liver tumor, liver transplantation, cholestasis, and congenital lipidosis, thus providing a valuable reference source for practitioners and researchers.

Spis treści

I Introduction.- The Intestine, Spleen, and Liver.- II Hepatic Sinusoidal Cells: Characteristics and Special Topics.- Endothelial Cells of the Hepatic Sinusoids: A Review.- Hepatic Stellate Cells.- Development, Differentiation, and Host Defense Function of Kupffer Cells.- Pit Cells as Liver-Associated Natural Killer Cells.- III Liver Diseases and Hepatic Sinusoidal Cells.- Liver Injury and Regeneration.- Changes in Adhesion Molecules of Sinusoidal Endothelial Cells in Liver Injury.- The Role of Hepatic Sinusoidal Cells in the Development of Massive Liver Necrosis.- Sinusoidal Endothelial Cells in Liver Regeneration.- Angiogenesis of Cultured Rat Sinusoidal Endothelial Cells.- The Multiple Roles of Macrophages in Hepatic Granuloma Formation in Mice.- Hepatic Sinusoidal Microcirculation.- Roles of Sinusoidal Endothelial Cells in the Local Regulation of Hepatic Sinusoidal Blood Flow—Involvement of Endothelins and Nitric Oxide.- Hepatic Innervation and Hepatic Sinusoidal Cells.- Contraction and Relaxation of Ito Cells.- Portal Hypertension and the Hepatic Sinusoid.- Alcoholic Liver Diseases and Hepatic Sinusoidal Cells.- Role of Sinusoidal Endothelial Cells in Alcoholic Liver Disease.- The Role of Neutrophils in Liver Cell Injury in Alcoholic Hepatitis.- Ethanol-Induced Perturbation of Hepatic Microcirculation: Roles of Endothelin-1 and Nitric Oxide in Regulation of Sinusoidal Tone.- Morphological Aspects of Hepatic Fibrosis and Ito Cells (Hepatic Stellate Cells), with Special Reference to Their Myofibroblastic Transformation.- Retinoids and Liver Fibrosis.- Hepatic Fibrolysis and Hepatic Sinusoidal Cells.- Diagnosis and Treatment of Hepatic Fibrosis and Hepatic Sinusoidal Cells.- Liver Tumor and Hepatic Sinusoidal Cells.- Anti-Fibrotic Agent Reduces Enzyme-Altered Lesions and Neoplasms in the Rat Liver.- VEGF Participates in Neovascularization and Sinusoidal Capillarization in HCC.- Natural Killer Cells in the Liver and Their Activators.- Modulation of Hepatic Sinusoidal Cell Function by Transduction of Genes in the Liver: Gene Therapy for Hepatic Micro-Metastasis.- Liver Transplantation and Hepatic Sinusoidal Cells.- Morphological Aspects of Hepatic Sinusoidal Walls in Reperfusion Injury after Liver Preservation for Liver Transplantation.- Ultrastructural and Functional Alteration in Hepatic Sinusoidal Cells in Cold-Preserved Rat Liver.- Others.- Cholestasis and Hepatic Sinusoidal Cells.- Congenital Lipidosis.- Key Word Index.