Liposomes in Drug Delivery: What, Where, How and When to deliver

ISBN-13: 9780443154911 / Miękka / 2024 / 440 str.

Spis treści

Part I - Basic concepts of Liposome-Assisted Drug Delivery 1. Introduction to Liposome Assisted Drug Delivery 2. Basic concepts of Liposome: components, structures, properties and classification 3. Liposome Characterization Methodologies(Physical and Chemical Methods) 4. Liposome Characterization Methodologies - Morphological Assessments by Microscopy 5. Liposome Stability and Integrity 6. In vivo fate of Liposomes: Biodistribution and cell membrane interactions Part II - Mechanisms of Liposome Drug Delivery 7. Liposomes in controlled drug delivery: Controlling drug release kinetics and biodistribution/pharmacokinetics 8. Liposome surface modifications-Engineering techniques 9. Activatable liposomes: Ultrasound-activated liposomes and lipid vesicles. Part III - Liposome Applications in drug delivery 10. Liposomes for drug delivery to the brain 11. Liposomes for drug delivery to cancer cells 12. Liposomes as vaccine delivery systems 13. Liposomes as DNA, mRNA and oligonucleotide delivery vectors 14. Liposomes for drug delivery by localized routes of administration 15. Liposome for drug delivery against infectious diseases 16. Liposomes for drug delivery via biomaterials 17. Liposomes for delivery of substances for other (non-therapeutic) applications Part IV -Liposome fabrication 18. Conventional methods for preparing liposomes of various types (MLVs, LUVs, SUVs ) 19. Size reduction, purification, sterilization and storage/packaging of Liposomes 20. Methods for preparation of Giant liposomes: Conventional methods; Modified electro-techniques 21. Microfluidic methods for liposome formation 22. Supercritical fluids and other novel methods for liposome formation 23. Design of experiment approaches for liposome property optimization 24. Development of generic liposome products for drug delivery Part V - Conclusions and Perspectives 25. Success stories, Final remarks and directions of the field