Liposomes in Analytical Methodologies

ISBN-13: 9789814669269 / Angielski / Twarda / 2016 / 480 str.

Katie A. Edwards

Opis

Liposomes have been widely explored in the drug delivery realm over the past decades. Many of the properties that made them well suited for drug delivery applications, such as the internal space to encapsulate a large payload of molecules and the inherent protection from exterior stresses, have also been exploited in various analytical techniques. Liposomes in Analytical Methodologies provides an extensive coverage of their utility, ranging from historic developments to actively researched techniques written by expert investigators. The introductory chapter serves as a primer on the fundamentals of liposomes for analytical purposes and provides an overview of various applications, while subsequent chapters provide in-depth coverage of selected areas. With techniques ranging from liposome PCR to electrophoretic separations, readers will gain an appreciation for the versatility that liposomes can add to the analytical toolbox.

Recenzje

"In the past 40 years since their discovery, liposomes have found widespread applications in biomimetic membrane research, drug delivery, and cosmetic encapsulation and in the topic of this book, as analytical reagents. This well-illustrated book has been written by recognized experts in the field of liposomal analysis and includes chapters on the most important applications and their relevant technologies. Liposomes in Analytical Methodologies is an outstanding review of the state of the art of using liposomes for analytical purposes."
—Prof. Richard A. Durst, Cornell University, USA

Spis treści

The analytical utility of liposomes: from the past to the present. Applications of liposomes in lateral flow assays. Application of liposomes in proteome microarrays for the study of lipid-protein interactions. Functional polydiacetylene liposomes as self-signaling and signal amplifying bio-and chemical sensor and sensor array. Taking advantage of liposomes in microfluidic systems. Redox liposomes in the development of electrochemical sensors. Coupling liposome-encapsulated nucleic acids with the polymerase chain reaction: a generic assay platform for high-sensitivity analyte detection. Magnetic liposomes in imaging and analysis. Liposome-based methodologies to assess pharmacokinetic parameters of drugs. Liposomes in capillary electromigration techniques. Fluorescent dye-encapsulating liposomes for cellular visualization.

O autorze

Katie A. Edwards is a scientist and lecturer at Cornell University. She earned her MS and PhD in toxicology from Cornell University and BS in chemistry from Clarkson University. Her work has primarily focused on the advancement of liposomes as analytical tools, utilizing her background in organic synthesis, lipid formulation, and novel biorecognition strategies to develop high-throughput laboratory-based methods and point-of-care diagnostics for analytes of environmental, national security, and clinical interest.