Lipoprotein(a)

ISBN-13: 9783031245749 / Angielski

Karam Kostner; Gerhard M. Kostner; Peter P. Toth

Opis

Lipoprotein(a) [Lp(a)] is a unique lipoprotein that has emerged as an independent risk factor for cardiovascular vascular disease.  Data from case control, epigenetic and mendelian randomization studies indicate that people with elevated Lp(a) have a two-fold to four-fold increased risk of cardiovascular events compared to people with low Lp(a) levels. Despite this risk, awareness of Lp(a) is still very low among health care providers. Even cardiologists often overlook Lp(a), in part because Lp(a) is not as well-understood as other risk factors and treatment options are still very limited.  This book offers an authoritative and comprehensive overview of Lipoprotein(a). It provides an in-depth review of all aspects of Lp(a), from pathophysiology to metabolism. Chapters offer the reader a contemporary view of the important roles of Lp(a) as a risk factor for cardiovascular disease. In addition, this volume discusses the clinical implications of elevated Lp(a) and current and future therapies.  Lipoprotein(a) is an essential resource for physicians, medical students, residents, fellows, and allied health professionals in lipidology, cardiology, endocrinology, pharmacotherapy, and health promotion and disease prevention.

Spis treści

Introduction: G.Kostner, K.Kostner, P.Toth

1.      History of Lp(a): Gert Uterman

2.      Biochemistry: Structure, Composition: G.Kostner

3.      Genetics of Lp(a): Florian Kronenberg

4.      Genetic Variants and Isoforms : Stefan Coassin

5.      Lp(a) and Lipid Oxidation: J.Witzum

6.      Metabolism: D.Rader

7.      Animal Models for Lp(a) Research: John Chapman

8.      Pathophysiology: M.Koschinsky, Sally McvCormick

9.       Possible Functions of Lp(a): P.Toth

10.   Lp(a) and Atherosclerosis: H.Ginsberg

11.   Role of Lp(a) as a CV Risk Factor: A.Catapano

12.   Prospective Studies for Risk assessment: W. März

13.   Lp(a) and Calcification: A.Langsted, PR Kamstrup

14.   When to measure Lp(a): K.Kostner

15.   Patients Perspectives: S.Tremulis

16.   Role of Lpa in Clotting and Thrombosis: P.Moriarty

17.   Lp(a) in Kidney Disease: H.Dieplinger

18.   Lp(a) and FH: G.Watts

19.   Epidemiology: B. Nordestgaard

20.   Lp(a) and  Mendelian Randomization: B.Ference,

21.   Assays for Lp(a) Measurement: D.Sullivan

22.   Lp(a) Standardization : S. Marcovina

23.   Referenz Methods and Reference Material: Ch.Cobbaert

24.   Therapy of elevated Lp(a): E.Stroes

25.   Antisense Therapy : S.Tsimikas

26.   Plasmapheretic Methods: U.Julius

27.   Open Questions: G.Kostner

O autorze

Karam Kostner, MD, Ph.D., FRACP,  FCSANZ

Associate Professor of Medicine

University of Queensland and Mater Hospital

Brisbane, Australia

Gerhard M. Kostner, Ph.D.

Emeritus Professor of Biochemistry and Molecular Biology

Medical University of Graz, Austria

Graz, Austria

Peter P. Toth, M.D. , PhD, FAHA, FESC, FACC

Adjunct Professor of Medicine

Division of Cardiology

Johns Hopkins University School of Medicine

Baltimore, Maryland  USA