Lipoprotein Subfractions Omega-3 Fatty Acids

ISBN-13: 9783540191469 / Angielski / Miękka / 1989 / 133 str.

H. U. Klar

Opis

On November 6 and 7, 1987, lipid and lipoprotein researchers from all over Europe convened in Munich on the occasion of the second European Workshop on Lipid Metabolism (EWLM). This informal gathering was devoted to two main topics, and recent research results were presented and discussed during a poster session. Recent developments in the physiology and pathophysiology of lipoprotein sub fractions were discussed on the first day of the meeting. In recent years, new analytical tools have been created for analyzing lipoprotein subfractions, particularly the apolipoprotein component. With the, introduction of immunological and elec trophoretic methods it has become clear that the heterogeneity of the plasma lipopro tein system is even greater than had been assumed only a decade or so ago. Despite this, it is apparent from the contributions to this volume that new methods for differentiating lipoprotein subfractions will increase our understanding of lipoprotein metabolism, especially of the triglyceride-rich lipoprotein particles and the high density lipoproteins. The complex functions of the various plasma apolipoproteins and their association with the lipoprotein lipid in single or complex lipoprotein particles give rise to a complex and dynamic metabolic system that changes constantly during the day. While it has for some time been possible to delineate fairly accurately the atherogenic potential of low-density lipoproteins, which are comparatively simple lipoprotein particles, the new methods of lipoprotein subfraction analysis will be needed to select and differentiate amongst the potentially atherogenic triglyceride rich particles, especially the chylomicron and very low density lipoprotein remnants."

Spis treści

Lipoprotein Subtractions; Their Role in Lipid Transport and Atherosclerosis.- The Lipoprotein Family Concept: An Update.- Ultracentrifugal, Chromatographic and Electrophoretic Techniques for Lipoprotein Subfractionation.- Analysis of Lipoprotein Particles Using Immunoaffinity Chromatography and ELISA Techniques.- Lipoprotein Association and Function of Apolipoprotein A-IV.- LP-X and Other Abnormal Lipoprotein Particles in Secondary Dyslipoproteinemia.- Turnover Studies of Apolipoproteins C: A First Critical Appraisal.- Lecithin: Cholesterol Acyl Transferase, Cholesterol Ester Exchange/Transfer Protein, and Lipoprotein Particles.- Role of the Liver in the Metabolism of Lipoprotein Particles.- LDL Subtractions and Atherosclerosis.- HDL Subclasses and Atherosclerosis.- Lipoprotein Deficiency Syndromes.- Significance of the Interaction Between Lipoprotein Subtractions and Macrophages for Reverse Cholesterol Transport.- HDL Receptor of Cultured Adipocytes and Its Role in Reverse Cholesterol Transport.- Omega-3 Fatty Acids.- Effects of Polyunsaturated Fatty Acids on Biochemical and Functional Aspects of Endothelial and Blood Cells.- Oxidative Metabolism of Unsaturated Fatty Acids and Free Radical Formation.- Omega-3 Fatty Acids and Hemostasis.- The Effects of Omega-3 Fatty Acids in Multiple Sclerosis: 2-Year Results.- Omega-3 Fatty Acids, Autoimmunity, and Diabetes.- Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Nutritional Needs and Dietary Recommendations.- Omega-3 Fatty Acid Treatment of Hyperlipidemia: Efficacy and Mechanisms of Action.