Life Extension: Lessons from Drosophila

ISBN-13: 9783319183251 / Angielski / Twarda / 2015 / 353 str.

Alexander Vaiserman; Alexey Moskalev; Elena Pasyukova

Opis

​This book looks at aging through research on Drosophila, the fruit fly that is one of the most widely used model organisms in bio gerontology. Work in model organisms can expand the theoretical knowledge of aging: it yields valuable insight into the molecular and cellular processes that underlie aging process, and it can perhaps provide new therapeutic targets for the treatment of age-related disorders in humans.Drosophila models have been developed for a large variety of aging-related processes and diseases, and this book provides readers with an overview of current research on the use of the Drosophila model to understand the genetic, molecular and physiological mechanisms that underlie the aging process. Themes of health span, life extension and longevity-associated genes emerge in this collation of international research on Drosophila that is of relevance to geriatrics and gerontology, animal genetics and genomics, and biomedicine.This fascinating, illustrated book will be of interest to a wide audience, ranging from academic researchers to the general reader.

Spis treści

Preface
Alexander M. Vaiserman, Alexey A. Moskalev, Elena G. Pasyukova

SECTION I: Genetic Regulation of Longevity

CHAPTER 1. Neuronal Genes and Developmental Neuronal Pathways in Drosophila Lifespan Control
Elena Pasyukova, Alexander Symonenko, Natalia Roshina, Mikhail Trostnikov, Ekaterina Veselkina, Olga Rybina

CHAPTER 2. Gadd45 Proteins in Aging and Longevity of Mammals and Drosophila
Alexey A. Moskalev, Ekaterina N. Plyusnina and Mikhail V. Shaposhnikov

CHAPTER 3. Superoxide Dismutase (SOD) Genes and Aging in Drosophila
John Tower

CHAPTER 4. Effect of Wolbachia Infection on Aging and Longevity-Associated Genes in Drosophila
Oleksandr M. Maistrenko, Svitlana V. Serga, Alexander M. Vaiserman and Iryna A. Kozeretska

 SECTION II: Drosophila Models for Aging-Associated Diseases

CHAPTER 5. Skeletal muscle homeostasis and aging in Drosophila
Melissa J. Puppa and Fabio Demontis

CHAPTER 6. Drosophila Models of Cardiac Aging and Disease
Alyson Sujkowski, Chelsea Richardson and Robert Wessells

CHAPTER 7. Parallels between Mammals and Flies in Inflammatory Bowel Disease
Theodoulakis Christofi and Yiorgos Apidianakis

CHAPTER 8. Protein Quality Control in Brain Aging: Lessons from Protein Misfolding Disorders in Drosophila
Lorena de Mena, Pedro Fernandez-Funez and Diego E. Rincon-Limas

CHAPTER 9. Drosophila Models in Therapeutic Drug Discovery Related to Aging
Charles Nichols

SECTION III: Life-Extending Treatments

CHAPTER 10. Life-Extending Effect of Phytochemicals in Drosophila
Lee Shin-Hae and Min Kyung-Jin

CHAPTER 11. Life Extension in Drosophila by Histone Deacetylase Inhibitors
Alexander M. Vaiserman and Elena G. Pasyukova

CHAPTER 12. An Evolutionary Analysis of Healthspan Extension Using Diet: Have We Come to the End of the Ponce de Leon Trail?
Grant A. Rutledge and Michael R. Rose

CHAPTER 13. Atmosphere, Metabolism and Longevity
Khatchik Muradian

CHAPTER 14. Effects of Mild Stresses Applied in Adults on Aging and Longevity
Éric Le Bourg

CHAPTER 15. Strategies for Stage-Specific Extension of Longevity
Robert Arking

Index