Leukemia: Recent Developments in Diagnosis and Therapy

ISBN-13: 9783642822513 / Angielski / Miękka / 2011 / 308 str.

E. Thiel; S. Thierfelder

Opis

Much of the attention presently paid to leukemia is the result of recent progress in understanding and treatment. Chemotherapy of leukemia started in the late 1940s, and combination therapy evolved in the late 1950s. It was at that time that the clonality of leukemia was realized, after the discovery of chromosomal and then biochemical and immunological markers. And now we have the new data on retroviral and cellular oncogenes and the reports on human T -cell lymphoma/ leukemia viruses. Many more steps forward could be enumerated in a field which is so rapidly making the hematological textbooks outdated. In this volume, thirteen in-depth reviews from large multicenter trials in the Federal Republic of Germany summarize the current state of diagnosis and management of leukemias. Childhood ALL and AML adult ALL and AUL were investigated. While cure appears to be achievable for more and more patients with acute leukemia, we still pursue the aim of optimal palliation in chronic leukemias. The management of patients with leukemia therefore varies to a large extent in aggressiveness of therapy. In some situations, rescue from an otherwise lethal disease is provided by bone marrow transplanta- tion, which is discussed in two chapters.

Spis treści

Current Understanding of Virus Etiology in Leukemia.- Cytogenetics in Leukemia: Implications for Pathogenesis and Prognosis.- Morphology, Cytochemistry, and Ultrastructure of Leukemic Cells with Regard to the Classification of Leukemias.- “Atypical” Leukemias: Preleukemia, Smoldering Leukemia and Hypoplastic Leukemia.- Biological and Clinical Significance of Immunological Cell Markers in Leukemia.- Acute Lymphoblastic Leukemia: Current Status of Therapy in Children.- Current Status of ALL/AUL Therapy in Adults.- Acute Myelogenous Leukemia: Current Status of Therapy in Children.- Acute Myelogenous Leukemia: Current Status of Therapy in Adults.- Management of CLL and Allied Disorders with Reference to Their Immunology and Proliferation Kinetics.- Management of Chronic Myelogenous Leukemia and Blastic Crisis.- Allogeneic Bone Marrow Transplantation in Leukemia.- Autologous Bone Marrow Transplantation in Leukemia.