Lessons from Animal Diabetes VI: 75th Anniversary of the Insulin Discovery

ISBN-13: 9781461286585 / Angielski / Miękka / 2012 / 420 str.

Eleazar Shafrir

Opis

genic constructs. Five articles are devoted to this topic ranging from the B-cell function in transgenic animals to the various effects on diabetes complications. The section on NIDDM, comprising of 10 articles, deals both with new and existing models, their particular widely varying pathogenesis, genetic character istics and complications. The animals reviewed include: spontaneously diabetic OLETF rats, Chinese hamsters, Goto-Kakizaki rats, db/db mice, rhesus monkeys, dogs and an article demonstrating the genetic link between the Zucker fa/fa and corpulent cp/cp obese interstrains. We wish to welcome the new members to our Editorial Board, Dr. Hubert Kolb from Dusseldorf, Dr. Alex Rabinovitch from Edmonton, Dr. Takayoshi Toyota from Sendai and Dr. Soroku Yagihashi from Hirosaki. At the same time we would like to thank Dr. Douglas L. Coleman from Bar Harbor and Dr. George Eisenbarth from Denver for their editorial contribution to the previous LAD Vol umes who have retired from the Editorial Board. With great sadness we have to mention Dr. Otho Michaelis IV from Beltsville, MD who suddenly passed away this year. Otho, or Mike as he was called by friends, made a significant contribution in developing and metabolically defin ing several strains of corpulent cp rats and was extremely helpful in the editor ial work of the LAD series. His contribution will remain in a lasting memory of all researchers of animal diabetes."

Spis treści

I Insulin Dependent Diabetes; B-Cell Function; B-Cell Destruction Mechanisms.- 1 Expression of glutamic acid decarboxylase (GAD) and its role as an autoantigen in insulin-dependent diabetes.- 2 Molecular genetics of insulin-dependent diabetes mellitus: Analysis of congenic strains.- 3 Role of macrophages and cytokines in B-cell death.- 4 Immunotherapy of insulin-dependent diabetes mellitus: Tolerance after short-term anti-Il-2 receptor/cyclosporine therapy in BB/OK rats.- 5 Role of retroviruses in the pathogenesis of diabetes with emphasis on the NOD mouse.- 6 Occurrence of pretype I diabetes (pre-IDDM) and type II diabetes (NIDDM) in BC1 [(NOD X Mus spretus) F1 X NOD] mice.- 7 Okamoto model for B-cell damage: Recent advances.- 8 Alloxan derivatives as a tool for the elucidation of the mechanism of the diabetogenic action of alloxan.- II Transgenic Animals In Diabetes Research.- 9 Role of glucokinase in regulation of insulin secretion: Lessons from transgenic mice.- 10 Consequences of human IAPP expression in transgenic mice.- 11 Immunostimulatory versus immunosuppressive roles of IL-10 in IDDM: Analysis with IL-10-producing transgenic NOD mice.- 12 Polyol accumulation versus diabetic retinopathy and nephropathy in transgenic mice expressing human aldose reductase.- 13 Transgenic hyperinsulinemia: A mouse model of insulin resistance and glucose intolerance without obesity.- III Non-Insulin-Dependent Diabetes: New Models And Update On Existing Models. Diabetes Complications And Therapeutic Modalities.- 14 Spontaneously diabetic rat “OLETF” as a model for NIDDM in humans.- 15 Glucose and lipid metabolism in the gold thioglucose injected mouse model of diabesity.- 16 Diabetes in the Chinese hamster.- 17 Studies on the pathogenesis of NIDDM in the GK (Goto-Kakizaki) rat.- 18 Role of immune and non-immune aspects of genetics in different expressions of diabetes in db/db mice.- 19 Inositols—Potential roles in insulin action and in diabetes: Evidence from insulin-resistant nonhuman primates.- 20 Antidiabetic characteristics of dehydroepiandrosterone in animal and human studies.- 21 Endoneurial vessel abnormalities in diabetic animal models.- 22 Dog and rat models of diabetic retinopathy.- 23 Glucose homeostasis in three interstrains (La/N-BN/Crl cp/cp; Zuc 13M-BN/Crl fa/fa; and Zucl3M-LA/N/fa/cp) of genetically obese rats.- Author Index.