Recent developments in lesion-symptom mapping (LSM) have spurred rapid growth. This volume provides comprehensive coverage of the steps and considerations involved in LSM. The chapters cover the definition and types of brain lesions, how to prepare them for analysis, standard LSM methods, network-based LSM methods, and approaches of transient lesions induced by brain stimulation. These chapters are supplemented by practical, hands-on mini tutorials on implementing the different analyses using freely-available software. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get started using LSM in your laboratory.
Cutting-edge and thorough, Lesion-to-Symptom Mapping: Principles and Tools connects core conceptual issues with available tools, making it a valuable resource for experienced and new researchers.
Shannon M. Sheppard, Andrea L.C. Schneider, and Argye E. Hillis
2. Manual Lesion Segmentation
Casey Ferrara, Branch Coslett, and Laurel Buxbaum
3. Automated Lesion Segmentation
Joseph C. Griffis and Dorian Pustina
4. Mapping the Spatial Distribution of Lesions in Stroke: Effect of Diffeomorphic Registration Strategy in the ATLAS Dataset
Brian B. Avants and Nicholas J. Tustison
5. Voxel-Based Lesion Symptom Mapping
Juliana V. Baldo, Maria V. Ivanova, Timothy J. Herron, Stephen M. Wilson, and Nina F. Dronkers
6. Statistical Considerations in Voxel-Based Lesion Behavior Mapping
Christoph Sperber and Hans-Otto Karnath
7. Voxel-Based Brain-Behavior Mapping in Neurodegenerative Diseases
Sladjana Lukic, Valentina Borghesani, Maria Luisa Gorno-Tempini, and Giovanni Battistella
8. Lesion Network Mapping: From a Topologic to Hodologic Approach
Amy Kuceyeski and Aaron Boes
9. Connectome-Based Lesion-Symptom Mapping using Structural Brain Imaging
Ezequiel Gleichgerrcht, Janina Wilmskoetter, and Leonardo Bonilha
10. Lesion Network Mapping using Resting State Functional Connectivity MRI
Juho Joutsa, R. Ryan Darby, and Michael D. Fox
11. Multivariate Lesion-Behavior Mapping
Yee-Haur Mah, Ashwani Jha, Tianbo Xu, and Parashkev Nachev
12. Lesion-Based Prediction and Predictive Inference
Daniel Mirman and Melissa Thye
13. Selecting and Handling Behavioral Measures for Lesion-Symptom Mapping
Peter E. Turkeltaub, Andrew T. DeMarco, and Maryam Ghaleh
14. Lesion-Behavior Awake Mapping with Direct Cortical and Subcortical Stimulation
Stephanie K. Ries, Kesshi Jordan, Robert T. Knight, and Mitchel Berger
15. Transcranial Magnetic Stimulation Mapping for Perceptual and Cognitive Functions
Samantha Strong and Edward H. Silson
Appendix A: Lesion-Symptom Mapping: Tools and Examples
1. Apprendix A Introduction
Dorian Pustina and Daniel Mirman
2. Lesion-Behavior Mapping Using NPM
Christoph Sperber
3. VLSM with VOXBO
Olufunsho K. Faseyitan
4. Get Software Running
Andrew T. DeMarco
5. Lesion Analysis with NiiStat Tutorial
Stefan Smaczny, Hannah Rosenzopf, and Lisa Röhrig
6. Lesion-Symptom Mapping Analyses using LESYMAP
Melissa Thye
7. Network Modification Tool 2.0
Keith Jamison and Amy Kuceyeski
Appendix B: Automated Segmentation: Tools and Examples
1. Appendix B Introduction
Dorian Pustina and Daniel Mirman
2. Automated Lesion Segmentation using LINDA
Melissa Thye
3. Overview of Automated Lesion Segmentation with lesion_gnb
Joseph C. Griffis
Subject Index List…
Recent developments in lesion-symptom mapping (LSM) have spurred rapid growth. This volume provides comprehensive coverage of the steps and considerations involved in LSM. The chapters cover the definition and types of brain lesions, how to prepare them for analysis, standard LSM methods, network-based LSM methods, and approaches of transient lesions induced by brain stimulation. These chapters are supplemented by practical, hands-on mini tutorials on implementing the different analyses using freely-available software. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get started using LSM in your laboratory.
Cutting-edge and thorough, Lesion-to-Symptom Mapping: Principles and Tools connects core conceptual issues with available tools, making it a valuable resource for experienced and new researchers.