Legionella Pneumophila: Pathogenesis and Immunity

ISBN-13: 9781441943651 / Angielski / Miękka / 2010 / 208 str.

Paul Hoffman; Herman Friedman; Mauro Bendinelli

Opis

Legionella pneumophila is an emerging human pathogen that resides in natural environments as a parasite of freshwater. There have been new developments in this field including the publication of three whole genome sequences, the discovery of a developmental cycle and novel cyst-like highly infectious form, and the bacteria have been used as a probe for macrophage cellular function to unravel fundamental new knowledge in the area of cellular biology. Legionella has also become a model system for the study of innate as well as adaptive immunity. Information on Legionella continues to increase in the U.S. and abroad. Columbia University has started the first Legionella Genome Project with a multi-million dollar grant from the NIH. In addition, The European Working Group for Legionella infections was formed in 1986. Members are scientists with an interest in improving knowledge and information on the clinical and environmental aspects of legionnaires' disease through developments in diagnosis, management and treatment of the disease. The volume brings together all of the lastest research on this pathogen, the interest in which is rapidly growing.

Recenzje

From the reviews:

"This small book ... starts with information on the bacterial genome and ends with the review of an effective immune response to infection. This book will serve to update the scientific and medical community with information that will allow for the rapid detection and treatment of ... infections. ... The audience for this book includes clinicians, laboratory personnel, and scientists ... . This compact reference full of good information ... is easy to read and allows for quick retrieval of desired information." (Rebecca T. Horvat, Doody's Review Service, August, 2008)

Spis treści

Legionella pneumophila Pathogenesis: Lessons Learned from Genomics.- Iron Assimilation and Type II Protein Secretion.- The Dot/Icm Type IVB Secretion System.- Life Cycle, Growth Cycles and Developmental Cycle of Legionella pneumophila.- Legionella in the Environment.- Regulation of the Legionella pneumophila Life Cycle.- Microbial Physiology.- Legionnaires’ Disease—Clinical Picture.- Legionella pneumophila:Innate and Adaptive Immunity.- Nonspecific Stimulation of Immunity Against Legionella.- Interaction of Legionella pneumophila with Amoeba.

O autorze

Legionella pneumophila is an emerging human pathogen that resides in natural environments as a parasite. It has been used as a probe for macrophage cellular function, which has led to new discoveries in cellular biology. Legionella has also become a model system for the study of innate as well as adaptive immunity. Information on Legionella continues to increase in the U.S. and abroad. Columbia University, for example, started the first Legionella Genome Project with a multi-million dollar grant from the NIH. In addition, The European Working Group for Legionella infections was formed in 1986. This volume brings together all of the latest research on this pathogen. Editor Herman Friedman is an acknowledged expert in the study of Legionella. He has assembled a team of distinguished and internationally recognized leaders in the field to contribute chapters in their respective areas of expertise.