Lassa Fever: Epidemiology, Immunology, Diagnostics, and Therapeutics

ISBN-13: 9783031358067 / Angielski / Twarda / 2023

Opis

This volume provides a comprehensive and up-to-date overview of the various aspects of Lassa virus (LASV), the causative agent of Lassa fever, a frequently fatal zoonotic disease endemic to West Africa. Compiled by world-leading experts in the field, this book provides an introduction to the 50-year history of Lassa fever research, the genetic diversity of LASV, and its geographic distribution. Subsequent chapters focus on the ecology and epidemiology of LASV, discussing in-depth the interactions of the virus with its hosts - multimammate mice and other rodents - and the interactions between these animal reservoirs and humans. The book also details the many advances in understanding the structural biology and replication of LASV, including new insights into the structure and function of its proteins. These advances in the basic understanding of LASV biology have enabled the development of LASV countermeasures, including sensitive and specific diagnostic assays. Promising drug candidates, including monoclonal antibodies, and vaccines are also discussed. A final and essential chapter addresses current and future clinical practice for clinical management of Lassa fever. 

This volume is intended for researchers and clinicians in the fields of virology, epidemiology, and microbiology.

Spis treści

1. 50 years of Lassa fever research

Robert F. Garry

2. Lassa Virus Genetics

Raphaëlle Klitting et al.

3. Ecology of Lassa virus

Allison R. Smither and Antoinette R. Bell-Kareem

4. Epidemiology of Lassa Fever

Antoinette R. Bell-Kareem and Allison R. Smither

5. Lassa virus countermeasures

Lilia I. Melnik

6. Lassa virus structural biology and replication

Robert F. Garry

7. Lassa Fever Natural History and Clinical Management

Donald S. Grant et al.

O autorze

Dr. Robert F. Garry is the manager of a partnership of scientists striving to deepen understanding of emerging pathogens such as Lassa virus. His efforts have led to the production of Lassa fever diagnostics and development of improved research and clinical infrastructure in West Africa. Here, he draws on those experiences to summarize essential knowledge about Lassa virus and to foreshadow important advances that are coming to control and treat of this important human pathogen.