Lasers for Ischemic Heart Disease: Update on Alternatives for the Treatment of Diffuse Coronary Artery Disease

ISBN-13: 9783642631986 / Angielski / Miękka / 2012 / 243 str.

Xavier M. Mueller

Opis

With the growing age of the general population, the proportion of elderly patients with diffuse coronary artery disease and severe comorbidities is increasing. When medical therapy cannot relieve the symptoms in these patients, their characteristics render them unsuitable for currently rec ognized invasive procedures, namely coronary artery bypass grafting and percutaneous transluminal angioplasty. There is an urgent need for new treatment modalities which can alleviate their symptoms and increase blood flow to the ischemic myocardium while being less inva sive for their fragile condition. The idea for this book was to relate my personal experience in the research and clinical fields and the current state of knowledge as reported in the literature. An additional aim was to provide anatomical and physiological background as well as a complete review of the new methods of revascularization currently being developed. To this purpose, I have analyzed many studies on the microvascula ture of the heart, the historical forerunners of the new procedures, and the new treatment modalities themselves: transmyocardiallaser revascu larization, therapeutic angiogenesis, and neurostimulation. I wish to thank my teachers in surgery, cardiology, and medicine: B. Faidutti (Geneva), J.-P. Berger (Vevey), 1. Kappenberger (Lausanne), F. Harder (Basel), T. Amery (Frimley), K. Arnold (Brig), and especially 1.K.

Spis treści

1 Historical Background.- 2 Microvascular Anatomy of the Heart.- 3 The Vineberg Procedure: A Forgotten Operation?.- 4 Myocardial Acupuncture: The Immediate Forerunner of Transmyocardial Laser Revascularization.- 5 Laser Physics.- 6 Laser Interaction with Tissue.- 7 Transmyocardial Laser Revascularization: Patient Selection, Operative Technique, and Perioperative Care.- 8 The Pioneering Era of Transmyocardial Laser Revascularization.- 9 Laser Channel Morphology.- 10 Pathophysiology of Transmyocardial Laser Revascularization.- 11 Clinical Results of Transmyocardial Laser Revascularization.- 12 Transmyocardial Laser Revascularization and Left Ventricular Function.- 13 Adverse Effects of Transmyocardial Laser Revascularization.- 14 Alternatives Forms of Transmyocardial Laser Revascularization.- 15 Angiogenesis: Pathophysiology.- 16 Therapeutic Angiogenesis: The Basis.- 17 Therapeutic Angiogenesis: Results.- 18 Combined Therapy: Transmyocardial Laser Revascularization and Therapeutic Angiogenesis.- 19 Neurostimulation.- Conclusions.- References.- Abbreviations.