Large-Scale Mammalian Cell Culture Technology

ISBN-13: 9780824783273 / Angielski / Twarda / 1990 / 656 str.

Lubiniecki; Anthony S. Lubiniecki

Opis

Presents an interdisciplinary approach, integrating biochemistry, biology, genetics, and engineering for the effective production of protein pharmaceuticals. This title offers a biological perspective of large-scale animal cell culture. It examines diverse processing strategies and process management.

Spis treści

Series Introduction, Series Introduction, Contributors, 1: Large-Scale Mammalian Cell Culture: A Perspective, 2: Use of Recombinant DNA Technology for Engineering Mammalian Cells to Produce Proteins, 3: Large-Scale Animal Cell Culture: A Biological Perspective, 4: Mammalian Cell Physiology, 5: Cell Banking, 6: Expression of Cloned Proteins in Mammalian Cells: Regulation of Cell-Associated Parameters, 7: Assay Requirements for Cell Culture Process Development, 8: Nonperfused Attachment Systems for Cell Cultivation, 9: Perfusion Systems for Cell Cultivation, 10: Suspension Culture of Mammalian Cells, 11: Microcarrier Culture Systems, 12: Microencapsulation of Mammalian Cells, 13: Continuous Culture with Macroporous Matrix, Fluidized Bed Systems, 14: Downstream Processing of Proteins from Mammalian Cells, 15: Management of Process Technology, 16: Monitoring and Control of Animal Cell Bioreactors: Biochemical Engineering Considerations, 17: Methods for the Detection of Adventitious Viruses in Cell Cultures Used in the Production of Biotechnology Products, 18: Continuous Cell Substrate Considerations, 19: Process Validation for Cell Culture-Derived Pharmaceutical Proteins, 20: Quality Control of rDNA-Derived Human Tissue-Type Plasminogen Activator, 21: Design and Construction of Manufacturing Facilities for Mammalian Cell-Derived Pharmaceuticals, 22: Large-Scale Propagation of Insect Cells, Index

O autorze

Anthony S. Lubiniecki