Part 1: Introduction 1. Lanthanide utilization by organisms: An Overview 2. Distribution and diversity of lanthanide-dependent methanol dehydrogenase, XoxF, in natural environments Part 2: Lanthanide-dependent methanol dehydrogenases in methylotrophs. 3. Discovery and gene function of mxa, pqq, and xox operons in Methylorubrum extorquens AM1 4. XoxF5 type-methanol dehydrogenase and lanthanide-dependent methylotrophy in Methylorubrum extorquens AM1 5. Lanthanide-dependent methanol and ethanol dehydrogenase isozymes in Methylorubrum extorquens AM1 Part 3: Regulation of lanthanide-dependent methanol metabolism in methylotrophs. 6. Regulation for activity and stability of XoxF5 by XoxJ, XoxG and Lanmodulin 7. Lanthanide uptake system and gene regulation of xox operon Part 4: Lanthanide-dependent methanol dehydrogenases in methanotrophs. 8. XoxF1-type methanol dehydrogenase and lanthanide-dependent methanotrophy in Methylacidiphilum fumariolicum 9. Molecular structure of XoxF1-type methanol dehydrogenase 10. Structure and function of the lanthanidedependent methanol dehydrogenase XoxF from Methylomicrobium buryatense Part 5: Regulation of lanthanide-dependent methanol metabolism in methanotrophs. 11. Regulation system of the lanthanidedependent methanol dehydrogenase an methanotrophy from Methylomicrobium buryatense 12. XoxF4-type lanthanide-dependent methanol dehydrogenase from Methylotenera mobilis and its molecular regulation by XoxG(4) Part 6: Lanthanide dependent methanol/alcohol dehydrogenase in non-methylotrophs 13. Lanthanide dependent methanol dehydrogenases in Rhizobia 14. Lanthanide dependent ethanol dehydrogenase from Pseudomonas Part 7: Application of lanthanide-dependent biological processes 15. Recovery of rare earth elements using lanmodulin 16. Development of lanthanide ion binding peptide 17. Biosynthesis of polyhydroxyalkanoate terpolymer from methanol via the reverse-oxidation pathway in the presence of Lanthanide 18. Switching Between Methanol Accumulation and Cell Growth by Expression Control of Methanol Dehydrogenase in Methylosinus