Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3: Basic Science and Clinical Relevance Part B

ISBN-13: 9781461352082 / Angielski / Miękka / 2012 / 1399 str.

David A. Sullivan; Michael E. Stern; Kazuo Tsubota

Opis

During the past several decades, a significant international research effort has been directed towards understanding the composition and regulation of the preocular tear film. This effort has been motivated by the recognition that the tear film plays a critical role in maintaining corneal and conjunctival integrity, protecting against microbial challenge and preserving visual acuity. In addition, research has been stimulated by the knowledge that alteration or deficiency of the tear film, which occurs in numerous individuals throughout the world, may lead to desiccation of the ocular surface, ulceration and perforation of the cornea, an increased incidence of infectious disease, and potentionally pronounced visual disability and blindness.

Spis treści

Claes H. Dohlman Conference Address. 1. Understanding Dry Eye Syndrome; K. Tsubota. Lacrimal Gland: Cellular And Molecular Biology. 2. GDNF Family Signaling in Exocrine Tissues: Distinct Roles for GDNF and Neurturin in Parasympathetic Neuron Development; J. Rossi, M.S. Airaksinen. 3. The Influence of Aging in the Insulin Signaling System in Rat Exocrine Glands; E.M. Rocha, et al. 4. Cloning, Partial Sequencing and Expression of Rabbit Lacrimal Grand beta-Hexosaminidase; J.P. Gierow, et al. 5. Differential Expression of Adenylyl Cyclase mRNAs in Lacrimal Glands of NZB/NZW and NOD Pre-Autoimmune Mice; M.A. Meneray, T.E. Lallier. 6. M3 Receptor Autoimmunity. Losing Tolerance to a Familair Protein; A.K. Mircheff, et al. 15 Additional Chapters. Lacrimal Gland And Ocular Surface: Signal Transduction, Membrane Traffic And Fluid And Protein Secretion. 22. Genetic Separation of the Human Lacritin Gene and Triple A (Allgrove) Syndrome on 12Q13; R. Kumar, et al. 23. Ca2 Signaling in Polarized Exocrine Cells; K. Kiselyov, et al. 24. Role of Ca2+ and Protein Kinase C in Cholinergic and alpha1-Adrenergic Agonists and EGF Stimulated Mitogen-Activated Protein Kinase Activity in Lacrimal Gland; J.D. Ríos, et al. 25. A Model of Fluid Secretion By the Acinar Cells of the Mouse Lacimal Gland; B. Walcott, et al. 26. Cytoskeletal Participation in Stimulated Secretion and Compensatory Apical Plasma Membrane Retrieval in Lacrimal Gland Acinar Cells; S.R. da Costa, et al. 10 Additional Chapters. Mucins: Origin, Properties, RegulationAnd Function. 37. Mechanism by Which Bacterial Flagellin Stimulates Host Mucin Production; N. McNamara, C. Basbaum. 38. Mucins and Ocular Surface Disease; S.H. Hibino, et al. 39. Functional Processing of Ocular Mucins; M. Berry, et al. 40. ERBB2 and its Ligand MUC4 (Sialomucin Complex) in Rat Lacrimal Gland; K.L. Carraway, et al. 41. Role of Mitogen-Activated Protein Kinase in Cholinergic Stimulation of Conjunctival Goblet Cell Secretion; D.A. Dartt, et al. 42. Isolation and Characterization of Human Goblet Cells in vitro: Regulation of Proliferation and Activation of Mitogen-Activated Protein Kinase by EGF and Carbachol; M.A. Shatos, et al. 43. Human Conjunctival Epithelium in Culture: A Tool to Assay New Therapeutic Strategies for Dry Eye; Y. Diebold, et al. 10 Additional Chapters. Meibomian Gland Art Tear Film Lipids: Structure, Function And Control. 54. Meibomian Gland and Tear Film Lipids: Structure, Function and Control; J.P. McCulley, W. Shine. 55. Androgen Regulation of Lipogenesis; J.V. Swinnen, et al. 56. Sex steroids, the Meibomian Gland and Evaporative Dry Eye; D.A. Sullivan, et al. 57. The Lipid Layer and Stability of Tears in Human Newborns; S.J. Isenberg, et al. 58. Interface Properties of Simplified Tear-Like Fluids in Relation of Lipid and Aqueous Layers Composition; F. Miano, et al. 15 Additional Chapters. Ocular Surface Homeostasis I: Tear Film Proteins & Stability. 74. The Tear Film and Defense Against Infection; S.M.J. Fleiszig, et al. 75. Nerve Growth Factor: An Impor