Laboratory Animal Endocrinology: Hormonal Action, Control Mechanisms and Interactions with Drugs

ISBN-13: 9780471972624 / Angielski / Twarda / 1997 / 576 str.

David D. Woodman;Woodman

Opis

Provides information covering the major laboratory animal species regularly used in experimental toxicology, including dogs, rodents and monkeys. The book examines historical perspectives, hormone structure, synthesis, secretion, receptors, second messages; their actions and the various physiological and pharmacological processes involved in endocrinological regulation, with a section devoted to drug effects and toxicology. Although data on drug effects is included, the book is not intended exclusively for toxicologists, and is also aimed at non-endocrinologists working with laboratory animals.

Spis treści

Organisation of Endocrine Systems.

Endocrine Evolution.

The Hypothalamus.

The Pituitary.

Thyroid and Parathyroid Hormones.

The Adrenal Glands.

Atrial Natriuretic Factor.

The Endocrine Pancreas.

Gastrointestinal Hormones.

Reproductive Hormones.

Endothelin.

Erythropoietin.

Index.

O autorze

About the Author Now a freelance toxicology consultant, David Woodman began his research career investigating the endocrine and physiological sequalae of stress in socially deviant populations. This initial interest in endocrinology and hormones led to many years in the pharmaceutical industry, where the author gained practical experience and expert knowledge in toxicology and drug safety with SmithKline Beecham.

Blurb

The complex and fascinating subject of endocrinology can often seem rather daunting for non–specialists. For practising endocrinologists too, maintaining a broad overview of the subject can be a major task. Laboratory Animal Endocrinology has been written with both these audiences in mind. Focusing on the species regularly used in experimental studies (including rodents, dogs and monkeys), each chapter presents a wealth of information on hormone structure, synthesis, secretion, receptors, second messengers and their actions, and considers the various physiological and pharmacological processes which may be involved in hormonal regulation. Interspecies′ differences in hormonal structure, metabolism and interactions with drugs and other chemicals are particularly important to toxicologists and in drug safety evaluation. Laboratory Animal Endocrinology also explores these areas of research and provides much–needed support for the interpolation of endocrine data from one test species to another and to humans. The book is not intended exclusively for toxicologists however, but will prove indispensable for all those working with laboratory animals.