Kidney Development and Disease

ISBN-13: 9783319514352 / Angielski / Twarda / 2017 / 372 str.

Rachel K. Miller

Opis

Kidney Development and Disease brings together established and young investigators who are leading authorities in nephrology to describe recent advances in three primary areas of research. The first section describes the use of animal models as powerful tools for the discovery of numerous molecular mechanisms regulating kidney development. The second section focuses on nephric cell renewal and differentiation, which lead to diverse cell fates within the developing kidney, and discusses diseases resulting from the aberrant regulation of the balance between cell fate decisions. The final section concentrates on morphogenesis of the developing kidney and its maintenance after formation as well as the diseases resulting from failures in these processes.
Kidney form and function have been extensively studied for centuries, leading to discoveries related to their development and disease. Recent scientific advances in molecular and imaging techniques have broadened our understanding of nephron development and maintenance as well as the diseases related to these processes.

Spis treści

A. Model Systems of Kidney Development and Disease: 

1. Madhu Tapadia   madhu@bhu.ac.in

Co-author: Naveen Gautam gautam.naveen6@gmail.com 

Topic: Drosophila Malpighian Tubule Development

2. Alan Davidson a.davidson@auckland.ac.nz 

Co-author: Richard Naylor

Topic: Zebrafish Nephron Formation

3. Rebecca Wingert rwingert@nd.edu 

Co-author: graduate student

Topic: Zebrafish as a model of kidney disease

4. Kelly McLaughlin kelly.mclaughlin@tufts.edu

Co-author: Shoshoni Caine

Topic: Use of Xenopus frogs to study renal development/repair

B. Cell Renewal, Differentiation and Fate in Nephrogenesis:

5.

Zubaida Saifudeen zubisaif@tulane.edu 

Topic: p53-Energy metabolism directed renewal vs differentiation

6. Peter Hohenstein peter.hohenstein@roslin.ed.ac.uk

Co-author: Derya Ozdemir Derya.Ozdemir@roslin.ed.ac.uk 

Topic: Wilms’ tumors and differentiation (tentative)

7. Leif Oxburgh oxburl@mmc.org 

Co-authors: Deepthi Muthukrishnan, Aaron Brown, Sarah McCarthy, Jennifer Fetting

Topic: Growth factor regulation in the nephrogenic zone

8. Wenzheng Zhang Wenzheng.zhang@uth.tmc.edu

Co-aut

hors: Lihe Chen and Paul Higgins Topic: Development and Diseases of the Collecting Duct 

9. Norman Rosenblum norman.rosenblum@sickkids.ca

Co-authors: Christopher Rowan and Sepideh Sheybani Deloui

Topic: Origin and function of the renal stroma in health and disease

C. Nephron Morphogenesis and Maintenance:

10. Ian Smyth ian.smyth@monash.edu 

Co-author: Kieran Short kieran.short@monash.edu 

Topic: integrating tissue morphology and cellular events during branching morphogenesis in the developing kidney

11. Kimberly Reidy kreidy@montefiore.org 

Topic: Polarity Proteins in Kidney Development and Disease (tentative)

12. Pamela Tran ptran@kumc.edu 

Topic: Cilia in Cystic Kidney Disease

13. Brad Yoder byoder@uab.edu 

Co-authors: Cheng Song song1c@uab.edu 

Kurt A Zimmerman zimmermk@uab.edu 

Topic: Inflammation and Fibrosis in Polycystic Kidney Disease

14.

Ana Sofia Cruz sofiacruzs@gmail.com

Co-authors: Arvind Bhimaraj and Keith Youker

Topic: Endothelial to Mesenchymal Transition in Kidney Fibrosis