Judah Folkman: A Biography

ISBN-13: 9783030064761 / Angielski / Miękka / 2019 / 124 str.

Domenico Ribatti

Spis treści

1. Biographic profile
2. Development of assays to study angiogenesis

2.1.The rabbit cornea

2.2.The chorioallantoic membrane

             2.3       Culture of endothelial cells

3. Tumor angiogenesis

3.1. Early evidence that tumor cells release specific growth factors for endothelial cells

3.2. Absence of angiogenesis in tumors in isolated perfused organs

3.3. Tumor growth is angiogenesis-dependent

3.4. The concept of angiogenic switch

3.5. The avascular and vascular phases of solid tumor growth

3.6. Angiogenesis and metastasis

3. 7. Prognostic significance of tumor vascularity

4. The discovery of angiogenic factors

4.1. Isolation of the first tumor angiogenesis factor

4.2. The discovery of FGF

4.3. The discovery of VPF/VEGF

5. Anti-angiogenesis

            5.1. Inhibition of angiogenesis by a diffusible factor from cartilage

5.2. Endogenous, direct and indirect inhibitors

5.3. Inteferon alpha

            5.4. Platelet factor 4/Protamine

            5.5. Angiostatic steroids

            5.6. Fumagillin

            5.7. Angiostain and endostatin

            5.8. Thalidomide

5.9. 2-methoxyestradiol and cleaved antithrombin III

           5.10. Anti-angiogenic chemotherapy

6. Concluding remarks

7. References

8. Publications of Judah Folkman (2014-1956)

           

 

Blurb

The aim if this book is to analyze the scientific biography of Judah Folkman, one of the most important scientist of the last century. More 50 years ago, Folkman found a revolutionary new way to think about cancer. Blood supply, Folkman hypothesized, was the key to tumor growth. Without new blood vessels, tumors simply did not thrive. In 1971, Folkman published his theory of angiogenesis in the “New England Journal of Medicine”. Angiogenesis, the formation and recruitment of new blood vessels, is necessary for tumor growth.  Critics of the theory were silenced over time as Folkman and his colleagues reported the first purified angiogenic molecule, the first angiogenesis inhibitor and proposed the concept of angiogenic disease. The mechanism of angiogenesis is now a worldwide field of investigation. Over the years, Folkman and a growing team of researchers have isolated the proteins and unraveled the processes that regulate angiogenesis. Meanwhile, a new generation of angiogenesis research has emerged as well, widening the field into new areas of human disease and deepening it to examine the underlying biological processes responsible for those diseases.