Investigations of Biological Principles of Swietenia Mahagoni

ISBN-13: 9783848447664 / Angielski / Miękka / 2012 / 128 str.

Mohammad Ahsanul Akbar; Rubina Ahamed; Mohammad Shawkat Ali

Opis

The study was designed for phytochemical investigations of ethanolic extract of bark and leaf of Swietenia mahagoni belonging to the family of Meliaceae and evaluation of their biological activities with the special emphasis on analgesic, anti-inflammatory, anti-microbial and cytotoxic screening in different animal model. Phytochemical investigations were done by extensive analysis with high resolution proton NMR spectroscopic data. The ethanol extract of stem bark was partitioned between pet-ether, dichloromethane and methanol fractions. Chromatographic isolation of dichloromethane fraction using column chromatography followed by preparative TLC afforded tetranortriterpenoid compound. Ethanol extract and different fractions showed significant analgesic and anti-inflammatory potential.From the bio-assay of different fractions and extract, significant cytotoxic properties were evaluated whereas mild to moderate antimicrobial activity was found in this study.

O autorze

Mohammad Ahsanul Akbar is a Lecturer of the Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Bangladesh and also a PhD student in the Department of Pharmaceutics, University of Florida, USA. His research interest is on molecular pharmacology, gene therapy and plant related bio-activity investigations.