Investigations in Yeast Functional Genomics and Molecular Biology

ISBN-13: 9781771880107 / Angielski / Twarda / 2014 / 412 str.

Matthew Eckwahl

Opis

This book examines conserved pathways mediating cell cycle progression and cell polarity establishment. It includes examples of yeast, regulatory circuits, and feedback regulation, with emphasis on system-wide approaches. It also covers protein interaction networks and trait locus analysis and presents methods and challenges in comparative genomics analysis and evolutionary genetics.

Spis treści

Introduction. Cell Polarity, Growth, and Cell Cycle. Daughter-Specific Transcription Factors Regulate Cell Size Control in Budding Yeast. Modeling Robustness Tradeoffs in Yeast Cell Polarization Induced by Spatial Gradients. Multisite Phosphorylation of the Guanine Nucleotide Exchange Factor Cdc24 during Yeast Cell Polarization. Yeast Regulatory Circuits. Roles of Candida albicans Gat2, a GATA-Type Zinc Finger Transcription Factor, in Biofilm Formation, Filamentous Growth and Virulence. Deciphering Human Heat Shock Transcription Factor 1 Regulation via Post-Translational Modification in Yeast. Environmental Regulation of Prions in Yeast. Heterologous Gln/Asn-Rich Proteins Impede the Propagation of Yeast Prions by Altering Chaperone Availability. Gene Expression and Trait Locus Analysis. Strategy of Transcription Regulation in the Budding Yeast. A Screen for RNA-Binding Proteins in Yeast Indicates Dual Functions for Many Enzymes. Genetic Landscape of Open Chromatin in Yeast. Comparative Genomics. High Quality de novo Sequencing and Assembly of the Saccharomyces arboricolus Genome. Comparative Gene Expression Between Two Yeast Species. Whole-Genome Comparison Reveals Novel Genetic Elements That Characterize the Genome of Industrial Strains of Saccharomyces cerevisiae. Index.

O autorze

Matthew Eckwahl is a graduate student at Yale University in the Department of Cell Biology, New Haven, Connecticut. He received his BS in molecular biology and biotechnology at the University of Michigan-Flint. Mr. Eckwahl has research experience in regulatory networks of psuedohyphal growth response and is currently working on the packaging of non-coding RNA by retroviruses.