Part I. The History of SIDS: 1. The history of SIDS – the Commonwealth's contributions in its formative years James R. Wright, Jr; Part II. The Parents: 2. When a baby dies, a community cries – family perspective Barbara Himes; 3. Care and support of parents after sudden and unexpected loss of an infant Monique L'Hoir and Maarten Witlox; Part III. Legal Framework: 4. Sudden infant death investigation in the UK – the coroner's perspective Christopher Dorries; 5. Investigating child deaths in the UK – the Police Perspective Phil Etheridge; 6. Sudden infant death investigation in the United States Andrew L. Falzon; Part IV. Best Practices Protocols of Investigation of Sudden Unexpected Death in Infancy and Childhood: 7. Emergency services: first responders Deborah A. Robinson; 8. The home visit Robert Coombs; 9. Autopsy: current methods and ancillary investigations Irene Scheimberg and Marta C. Cohen; 10. The joint forensic/pediatric post-mortem examination Alfredo E. Walker; 11. Minimally invasive autopsy Elspeth Whitby, Ashok Raghavan and Amaka Offiah; 12. Child death review: an effective approach for the surveillance of sudden and unexplained infant deaths in the US Theresa M. Covington; 13. Final case discussion and child death review panels (CDOP) in the UK Joanna Garstang and Peter Sidebotham; Part V. Autopsy Findings: 14. Imaging findings on autopsy Elspeth Whitby, Ashok Raghavan and Amaka Offiah; 15. Neuropathology of SIDS Waney Squier; 16. Postmortem microbiology: sampling and interpretation Amparo Fernández-Rodríguez; 17. The investigation of poisoning in infants and young children Robert J. Flanagan; 18. Inherited metabolic disease and sudden unexplained death in infancy and childhood: post-mortem samples and investigations Simon E. Olpin; Part VI. Epidemiology and Risk Factors: 19. Biological factors Fern R. Hauck; 20. Risk of recurrent sudden infant death syndrome in families Carl E. Hunt; 21. Prenatal and postpartum nicotine exposure Adèle Engelberts; 22. Misuse of drugs in pregnancy Marta C. Cohen and Robert Coombs; 23. Environmental risk factors for SIDS Michael Goodstein; 24. The relationship between breastfeeding and SIDS John M.D. Thompson; 25. Pacifier use and SIDS Alejandro Gustavo Jenik; 26. Bedsharing: what is the evidence? Peter S. Blair, David Tipene-Leach and Eve R. Colson; 27. Day care environment Rachel Moon; Part VII. Pathophysiology: 28. The genetics of sudden infant death syndrome James Steer and Srinivas Annavarapu; 29. Cardiac arrhythmias Chris Miles and Elijah Behr; 30. Sudden infant death syndrome from the brainstem perspective Jan-Marino Ramirez and Christopher G. Wilson; 31. Arousal and risk factors for SIDS Robert A. Darnall; 32. Serotonin abnormalities in the brainstem of sudden infant death syndrome Robin L. Haynes; 33. Inner ear abnormalities in SIDS Daniel D. Rubens and Sanja Ramirez; 34. Inherited metabolic disease and sudden unexplained death in infancy and childhood: pathophysiology Simon E. Olpin; Part VIII. SUDI/SUID which is not SIDS: 35. Causes of sudden unexpected death in infancy (other than SIDS) Irene Scheimberg and Phillip Cox; 36. Forensic pathology aspects of sudden unexpected death in infancy and childhood Michael J. Shkrum and David A. Ramsay.