Introduction to Statistical Methods in Modern Genetics

ISBN-13: 9780367398903 / Angielski / Miękka / 2019 / 247 str.

M. C. Yang

Opis

Though the basic statistical theory behind modern genetics is not that difficult, most statistical genetics papers are not easy to read for beginners, and fitting formulae to a particular area of application quickly becomes very tedious. Introduction to Statistical Methods in Modern Genetics makes a clear distinction between the necessary and unnecessary complexities. The author keeps the derivations of methods simple without losing the mathematical details. He also provides the necessary background in modern genetics for newcomers to the field, including discussion ranging from biological and molecular experiments to gene hunting and genetic engineering.

Spis treści

BACKGROUND TO MODERN STATISTICAL GENETICS
Introduction: Where is the Gene?
Function of Genes in Reproduction
Some Facts in Molecular Genetics
Tools in Molecular Genetics
Genetic Engineering
Exercise 1
LINKAGE ANALYSIS WITH QUALITATIVE TRAIT
Basic Concepts in Pedigree Analysis
Linkage analysis for Large Pedigrees
Incomplete Penetrance and Sibling Studies
Designs in Linkage Analysis
Exercise 2
GENETICS OF QUANTITATIVE TRAIT
Quantitative Trait Locus (QTL) Based on Sibpairs
Interval Mapping of Quantitative Trait Loci
Heritability Estimation
Breeding Value Evaluation Models
Exercise 3
SPECIAL TOPICS
Small Area Gene Mapping by Linkage Disequilibrium
Gene, Exon, and Intron Identification
Reconstruction of Evolutionary Path
Forensic Evidence Using Genetic Markers
Exercise 4
APPENDIX A: STATISTICAL RESULTS USEFUL IN GENETICS
Multivariate Analysis and Regression
Likelihood Ratio Test and General Linear Models
Multinomial Distribution
Inference on Frequency Tables
Discriminant Analysis and Neural Network
APPENDIX B: SELECTED PUBLIC DOMAIN COMPUTER PROGRAMS FOR GENETIC DATA ANALYSIS
A Teaching Linkage Analysis Program for Two Generation Families
A Simulation Program to Computer ELOD and Var(LOD) for Two Generation Families
Liped and Programs Described in Terwilliger and Ott's Handbook
Simlink - Power Prediction for Given Pedigress
SIB-PAIR; A Nonparametric Linkage Software
MAPMAKER/SIBS, MAPMAKER/QTL, Genehunter, GAS
A SAS Program to Computer Kinships Coefficients
Using SAS-IML to Solve Handerson's Equation
ETDT
GeneBank and Genetic Data Sources

Answers or Hints to Exercises
Bibliography

O autorze

Yang, M.C.