Intracellular Traffic and Neurodegenerative Disorders

ISBN-13: 9783642099724 / Angielski / Miękka / 2010 / 184 str.

Peter H. St George-Hyslop; William C. Mobley

Opis

Neurodegenerative disorders are common and devastating. Rationally, the most effective treatments will target pathogenetic mechanisms. While alternative - proaches, based on alleviating the symptoms of patients with Alzheimer disease, Parkinson disease, Huntington disease, prion disorders or amyotrophic lateral sc- rosis, can be expected to reduce suffering, studies of pathogenesis of these a- related disorders will be most important for enabling early diagnosis and the creation of preventative and curative treatments. It is in this context that a recent IPSEN rd meeting (The 23 Colloque Medecine et Recherche, April 28, 2008) focused on a role for disruption of intracellular traf?cking in neurodegenerative disorders. The meeting captured emerging insights into pathogenesis from disrupted traf?cking and processing of proteins implicated in age-related degeneration. Protein folding, traf?cking and signaling were the principal topics covered at the meeting. Importantly, the presenters pointed to the importantly intersection of these themes. While the proteolytic processing of APP into its toxic product, the A? peptide, is an intensive focus of work in many laboratories, it is only relatively recently that investigators have begun to examine in depth the cellular compartments and traf?cking events that mediate APP processing and how derangement of tr- ?cking pathways could impact them."

Recenzje

From the reviews:

"This monograph is an up to date account of the abnormalities in axonal transport of proteins and molecules in neurons in the aging and diseased brain. ... This book is meant for neuropathologists, neurologists, and advanced graduate students in the Neurosciences. I can recommend it for these professionals without hesitation." (Joseph J. Grenier, Amazon.com, November, 2013)

Spis treści

Amyloid Precursor Protein Sorting and Processing: Transmitters, Hormones, and Protein Phosphorylation Mechanisms.- Intramembrane Proteolysis by ?-Secretase and Signal Peptide Peptidases.- Axonal Transport and Neurodegenerative Disease.- Simple Cellular Solutions to Complex Problems.- Tau and Intracellular Transport in Neurons.- Signaling Between Synapse and Nucleus During Synaptic Plasticity.- Axonal Transport of Neurotrophic Signals: An Achilles' Heel for Neurodegeneration?.- Membrane Trafficking and Targeting in Alzheimer's Disease.- Huntington's Disease: Function and Dysfunction of Huntingtin in Axonal Transport.- The Role of Retromer in Neurodegenerative Disease.- Regulation of Endocytic Trafficking of Receptors and Transporters by Ubiquitination: Possible Role in Neurodegenerative Disease.- The Sortilin-Related Receptor SORL1 is Functionally and Genetically Associated with Alzheimer's Disease.- Regulation of Transport and Processing of Amyloid Precursor Protein by the Sorting Receptor SORLA.

Blurb

This book explores the role of sub-cellular trafficking in the pathogenesis, treatment and prevention of neurodegenerative diseases. Recent findings point to faulty trafficking as contributing to the dysfunction and degeneration of neurons and neural circuits. Increasingly, research is targeting the mechanisms responsible and means to address them therapeutically. Many adult onset neurodegenerative diseases appear to arise from the accumulation of misfolded, neurotoxic peptides. This book investigates the ways in which sub-cellular trafficking pathways play a role both in the pathological accumulation of these misfolded proteins and in attempts to clear them. Because subcellular protein trafficking has an important role in the biology of neuronal function and survival, this also addresses how trophic factors maintain cell: cell interactions and how the underlying mechanisms may be compromised in neurodegenerative diseases. Examples where the use of such trophic factors may provide a way to modify neurodegenerative diseases are investigated.