Intestinal Tumorigenesis: Mechanisms of Development & Progression

ISBN-13: 9783319346243 / Angielski / Miękka / 2016 / 445 str.

Vincent W. Yang; Agnieszka B. Bialkowska

Spis treści

.-1 Hereditary CRC syndrome

.-2 Microsatellite Instability and Intestinal Tumorigenesis

.-3 Biology of Intestinal Epithelial Stem Cells

.-4 The role of PI3K Signaling Pathway in Intestinal Tumorigenesis

.-5 The Epigenetics in Intestinal Tumorigenesis

.-6 MicroRNA involvement in Intestinal Tumorigenesis

.-7  Microbiome implications in Intestinal Tumorigenesis

.-8 Inflammation and Colorectal Cancer

.-9 Sphingolipids in Intestinal Inflammation and Tumorigenesis

.-10 Aging: an Etiological factor in the Development of Intestinal Tumorigenesis

.-11 Epithelial to Mesenchymal Transition [EMT] and Intestinal Tumorigenesis

.-12 Omics and biomarkers development for Intestinal Tumorigenesis

.-13 Targeted Therapies towards Intestinal Tumorigenesis             

O autorze

Vincent W. Yang, MD, Ph.D, is a nationally recognized physician, scientist, and gastrointestinal cancer investigator. He is the Simons Chair of the Department of Medicine at Stony Brook University. He is also a Professor in the Department of Medicine, with a joint appointment as a Professor in the Department of Physiology & Biophysics. Dr. Yang is on the editorial board of such journals as the American Journal of Medicine, Translational Oncogenomics, World Journal of Gastroenterology, American Journal of Physiology-Gastrointestinal, and Liver Physiology. Throughout his career, Dr. Yang has received several awards and honors. He has published over 130 scientific papers and has been cited over 5,000 times.

 Agnieszka Bialkowska, Ph.D, is a Research Assistant Professor in the Department of Medicine at Stony Brook University. She specializes in the mechanisms of development and progression of colorectal cancer. Dr. Bialkowska is also a Senior Research Scientist in Dr. Vincent W. Yang's lab. She has published over 20 scientific papers.

Blurb

​This volume includes the information necessary to understand recent critical advances in the mechanisms of intestinal tumorigenesis and to comprehend the complexity of the process. The volume aims to entice new researchers to participate in relevant studies, and to provide a forum for discussion within the scientific community to shape future research in this field. Discoveries in intestinal tumorigenesis lead to further understanding of mechanisms involved in colon cancer. Additionally, advancements in techniques and methods open the doors for new approaches to better define the molecular and organismal mechanisms of intestinal tumorigenesis. Chapters are authored by widely published authorities in the field.

Each year, there are close to 150,000 new cases of colorectal cancer, which results in approximately 50,000 deaths per year in the United States; these figures render colorectal cancer a significant health concern. Studies attempting to understand the mechanisms of development and progression of colorectal cancer have been ongoing for decades and each year brings new discoveries yielding a better comprehension of the underlying processes at work.