Interaction Between Neurons and Glia in Aging and Disease

ISBN-13: 9781441943606 / Angielski / Miękka / 2010 / 521 str.

Joao Malva

Opis

Interactions Between Neurons and Glia in Aging and Disease is a source of "reference reviews" and "concise overviews" of the functional cross-talk between neurons and glial cells, with a focus on microglia and inflammation in the aging brain and in neurological disorders. The scientific area covered by this book may be considered of key interest, and it is recognized, by the scientific community, as a major competitive area with critical implications for human health. This book is organized in three main sections that are expected to guide the readers from the basic functional cross-talk between neuron and glia to brain pathology. The specific proposed sections are: 1) Neuroimmunity and Neuroinflammation; 2) Signalling and inflammation in aging; 3) Neurodegeneration and inflammation in age related diseases.

Spis treści

Neuroimmunity and neuroinflammation.- Inflammation and Neuronal Susceptibility to Excitotoxic Cell Death.- Microglial Cell Population Expansion Following Acute Neural Injury.- Opposite Modulation of Peripheral Inflammation and Neuroinflammation by Adenosine A2A Receptors.- Subventricular Zone Cells as a Tool for Brain Repair.- Signaling and inflammation in aging.- Neuron-Glia Interaction in Homeostasis of the Neurotransmitters Glutamate and GABA.- The Impact of an Imbalance Between Proinflammatory and Anti-inflammatory Influences on Synaptic function in the Aged Brain.- Neurotrophin Signaling and Cell Survival.- GDNF: a Key Player in Neuron-Glia Crosstalk and Survival of Nigrostriatal Dopaminergic Neurons.- Molecular Pathways of Mitochondrial Dysfunction in Neurodegeneration: the Paradigms of Parkinson's and Huntington's Diseases.- Zinc Homeostasis and Brain Injury.- Aging and Cognitive Decline: Neuroprotective Strategies.- Neurodegeneration and inflammation in age related diseases.- Inflammation and Apoptotic Pathways in the Peripheral Nervous System Related to Protein Misfolding.- Neuroinflammation and Excitotoxicity in Neurobiology of HIV-1 Infection and AIDS: Targets for Neuroprotection.- Neuroinflammation and Mitochondrial Dysfunction in Alzheimer's and Prion's Diseases.- Metal Ions and Alzheimer's Disease.- Epilepsy, Brain Injury and Cell Death.- Glia and Hippocampal Neurogenesis in the Normal, Aged and Epileptic Brain.- Polyglutamine Expansion Diseases – the Case of Machado-Joseph Disease.- Remyelination of the Central Nervous System.- Adult Neurogenesis in Neurodegenerative Diseases.- ATP Receptors in the Pain Signaling: Glial Contribution in Neuropathic Pain.- Diabetic Retinopathy, Inflammation, and Proteasome.- Rejuvenating Neurons and Glia with Microbial Enzymes.

Blurb

Interactions Between Neurons and Glia in Aging and Disease is an indispensable source of reference reviews and concise overviews of the functional cross-talk between neurons and glial cells. This key title specifically focuses on microglia and inflammation in the aging brain and in neurological disorders. The subject material covered by the book is a crucial competitive area with critical implications for human health and will be of key interest to the scientific community.

Interactions Between Neurons and Glia in Aging and Disease is broken into three main sections to help guide the reader from the basic functional cross-talk between neuron and glia to brain pathology.

• Neuroimmunity and neuroinflammation
• Signalling and inflammation in aging
• Neurodegeneration and inflammation in age related diseases

This unique volume will be invaluable not only to those interested in neuroscience, but also cell biology, molecular biology, biochemistry, and pharmaceutical sciences.