Integrins: Molecular and Biological Responses to the Extracellular Matrix

ISBN-13: 9780121711603 / Angielski / Twarda / 1994 / 278 str.

Cheresh; Robert P. Mecham; David A. Cheresh

Opis

Integrins: Molecular and Biological Responses to the Extracellular Matrix will help basic, applied, and clinical researchers keep up with the explosion of literature on the integrin family of proteins. This volume extends material previously covered in Receptors for Extracellular Matrix. It addresses some of the most exciting areas of integrin biology, including the varied roles of integrins in cell division, differentiation, movement, wound healing, inflammation, thrombosis, osteoporosis, and cancer.

• Describes key aspects of integrin structure, function, and biology
• Covers collagen receptors, epithelial cell integrins, leukocyte integrins, platelet integrins, integrin signaling, and integrin antagonists
• Investigates the expression and role of integrins during development and in the cytoskeleton
• Includes the actions and influences of integrins in inflammation, thrombosis, and osteoporosis

Spis treści

The Structural Basis of Integrin-Ligand (RGD) Interaction
Integrins as Signal Transducing Receptors
Interactions Between Integrins and the Cytoskeleton: Structure and Regulation
Integrins, Signaling, And the Remodeling of the Extracellular Matrix
Integrins in Development
Distinctive Functions of Alpha6beta4 and Other Interactions in Epithelial Cells
Leukocyte Integrins
Molecular Properties of Human Platelet Integrin Alphaiibbeta3
Therapeutic Potential of Integrin Antagonists