Insight on Genotoxicity

ISBN-13: 9780367473372 / Angielski / Twarda / 2020 / 170 str.

Shiv Shankar Shukla; Ravindra Kumar Pandey; Bina Gidwani

Opis

This book examines the impact of ICH Guidelines on genetic toxicity testing which is a regulatory requirement for drug discovery and development. Genetic toxicity mechanism has also been discussed in detail with a wider perspective.

Spis treści

Introduction to Genotoxicity. Genotoxicity and DNA Repair. Consequence of DNA Damage. Mechanism of Genotoxicity. Impact of ICH Guidelines on Genotoxicity Testing: Dogmatic Obligation for Innovation Drug Discovery and Development. Genotoxicity Prediction. Computational prediction. Computational prophecy of Genotoxicity with models. Bioindicator of Genotoxicity: The Allium cepa Test. Genotoxicity appraisal of Nano sized material and particles. Genotoxicity Evaluation in Phytopharmaceuticals: Perspective Review. Deterrence of Genotoxicity: Brief Perspective. Genotoxic and non-genotoxic chemicals for review of the performance improved genotoxicity. Genotoxic impurities in Pharmaceuticals. Genotoxicity and carcinogenicity predictive software systems. Poultry manure Induced DNA Damage. Expert opinion on the basis of the content and easy understandable rundown for the reader.